Samuel J Danishefsky
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Explore the profile of Samuel J Danishefsky including associated specialties, affiliations and a list of published articles.
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247
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3848
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Recent Articles
1.
Dai M, Danishefsky S
Heterocycles
. 2024 Dec;
77(1):157-161.
PMID: 39669876
The feasibility of a hypervalent iodine-mediated oxidative dearomatization/cyclization to produce the oxabicyclo[3.2.1]octene of cortistatin A has been demonstrated through a model study. An interesting tandem cyclization via a Ritter intermediate...
2.
3.
Li Y, Tran A, Danishefsky S, Tan Z
Methods Enzymol
. 2019 May;
621:213-229.
PMID: 31128780
Recent advances have demonstrated the feasibility and robustness of chemical synthesis for the production of homogeneously glycosylated protein forms (glycoforms). By taking advantage of the unmatchable flexibility and precision provided...
4.
Brailsford J, Stockdill J, Axelrod A, Peterson M, Vadola P, Johnston E, et al.
Tetrahedron
. 2019 Mar;
74(15):1951-1956.
PMID: 30853725
The β-subunit of human thyroid stimulating hormone (hTSH) has been synthesized as a single glycoform bearing a chitobiose disaccharide at the native glycosylation site. Key to the successful completion of...
5.
Ragupathi G, Slovin S, Adluri S, Sames D, Kim I, Kim H, et al.
Angew Chem Int Ed Engl
. 2018 May;
38(4):563-566.
PMID: 29711780
Human trials on the globo H carbohydrate vaccine (see picture, KLH=the carrier protein keyhole limpet hemocyanin) show that it produces strong IgM, and in some cases IgG, responses in patients...
6.
Wu Z, Williams L, Danishefsky S
Angew Chem Int Ed Engl
. 2018 May;
39(21):3866-3868.
PMID: 29711678
No abstract available.
7.
Balog A, Harris C, Savin K, Zhang X, Chou T, Danishefsky S
Angew Chem Int Ed Engl
. 2018 May;
37(19):2675-2678.
PMID: 29711598
The stabilization of the transition state through a favorable interaction between the double bond of 1 and the carbonyl group of 2 appears to be responsible for the high diastereoface...
8.
Meng D, Danishefsky S
Angew Chem Int Ed Engl
. 2018 May;
38(10):1485-1488.
PMID: 29711567
A reaction sequence made up of a Sakurai reaction, ketene cyclization, sulfur-directed Baeyer-Villiger reaction, and tandem lactone cleavage/isomerization provided the fully functionalized core of the CP compounds. Key steps were...
9.
Chen X, Zhou B, Bhattacharya S, Gutteridge C, Pettus T, Danishefsky S
Angew Chem Int Ed Engl
. 2018 May;
37(6):789-792.
PMID: 29711384
An "sp -sp Stille coupling" of the vinyl triflate 1 and the stannyl compound 2 is a key step toward the completion of the total synthesis of eleutherobin, a natural...
10.
Zheng C, Seeberger P, Danishefsky S
Angew Chem Int Ed Engl
. 2018 May;
37(6):786-789.
PMID: 29711374
A new general method for the preparation of N-acetylglucosamine glycosidic linkages has been developed for solid-phase synthesis. The complete pentasaccharide domain of the Lewis blood group antigen, which is a...