Rajesh Kakadiya
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Explore the profile of Rajesh Kakadiya including associated specialties, affiliations and a list of published articles.
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22
Citations
116
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Recent Articles
1.
Detroja D, Chen T, Lin Y, Yen T, Wu M, Tsai T, et al.
Anticancer Agents Med Chem
. 2017 May;
17(13):1741-1755.
PMID: 28530540
Background: Bendamustine, an N-mustard-benzoimidazole hybrid conjugate, was recently approved for the treatment of chronic lymphocytic leukemia. However, the short half-life of bendamustine may limit its clinical applications. Objective: The purpose...
2.
Sanjiv K, Chen C, Kakadiya R, Tala S, Suman S, Wu M, et al.
Transl Oncol
. 2017 Mar;
10(2):295-296.
PMID: 28292510
No abstract available.
3.
Viradiya D, Mirza S, Shaikh F, Kakadiya R, Rathod A, Jain N, et al.
Anticancer Agents Med Chem
. 2016 Dec;
17(7):1003-1013.
PMID: 27924733
Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2...
4.
Kuo H, Kakadiya R, Wu Y, Su T, Lee T, Lin Y, et al.
Oncotarget
. 2016 May;
7(25):38078-38090.
PMID: 27191263
Autophagy is a lysosomal degradative process that protects cancer cells from multiple types of stress. In this study, we synthesized a series of derivatives of 6-cinnamamido-quinoline-4-carboxamide (CiQ), and investigated their...
5.
Kuo C, Chou W, Wu C, Wong T, Kakadiya R, Lee T, et al.
Oncotarget
. 2015 Jul;
6(28):25770-83.
PMID: 26208482
Alkylating agents are frequently used as first-line chemotherapeutics for various newly diagnosed cancers. Disruption of genome integrity by such agents can lead to cell lethality if DNA lesions are not...
6.
Marvania B, Kakadiya R, Christian W, Chen T, Wu M, Suman S, et al.
Eur J Med Chem
. 2014 Jul;
83:695-708.
PMID: 25014640
We synthesized a series of phenyl N-mustard-4-anilinoquinoline conjugates to study their antitumorigenic effects. These agents were prepared by the condensation of 4-[N,N-bis(2-chloroethyl)amino]phenyl isocyanate with 6-amino-4-methylamino or 4-anilinoquinolines. The structure-activity relationship...
7.
Sanjiv K, Chen C, Kakadiya R, Tala S, Suman S, Wu M, et al.
Transl Oncol
. 2014 Jun;
7(2):256-266.e5.
PMID: 24913674
The synergistic targeting of DNA damage and DNA repair is a promising strategy for the development of new chemotherapeutic agents for human lung cancer. The DNA interstrand cross-linking agent BO-1509,...
8.
Tala S, Ou T, Lin Y, Tala K, Chao S, Wu M, et al.
Eur J Med Chem
. 2014 Mar;
76:155-69.
PMID: 24583355
A series of new, water-soluble phenyl N-mustard-benzenealkylamide conjugates containing hydrophilic ω-dialkylaminoalkylamide or ω-cyclic aminoalkylamide moieties were synthesized via a bioisostere approach. These compounds have a broad spectrum of antitumor activity...
9.
Su T, Lee T, Kakadiya R
Eur J Med Chem
. 2013 Oct;
69:609-21.
PMID: 24095754
Bifunctional DNA cross-linking agents are widely used as chemotherapeutic agents in clinics. The advance in the development of these agents as potential antitumor agents has generated various types of bis(hydroxymethyl)pyrrole...
10.
Chaniyara R, Tala S, Chen C, Zang X, Kakadiya R, Lin L, et al.
J Med Chem
. 2013 Jan;
56(4):1544-63.
PMID: 23360284
A series of bis(hydroxymethyl)indolizino[6,7-b]indoles and their bis(alkylcarbamates) were synthesized for antitumor studies. These agents were designed as hybrid molecules of β-carboline (topoisomerase inhibition moiety) and bis(hydroxymethyl)pyrrole (DNA cross-linking moiety). The...