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Tina Lence

Explore the profile of Tina Lence including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 987
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Recent Articles
1.
Lence T, Sulzer J, Andress K, Gribling-Burrer A, Lamm-Schmidt V, Barquist L, et al.
PLoS Biol . 2024 Dec; 22(12):e3002948. PMID: 39671441
Bacterial noncoding RNAs fulfill a variety of cellular functions as catalysts, as scaffolds in protein complexes or as regulators of gene expression. They often exhibit complex tertiary structures that are...
2.
Fuchs M, Lamm-Schmidt V, Lence T, Sulzer J, Bublitz A, Wackenreuter J, et al.
EMBO J . 2023 May; 42(12):e112858. PMID: 37140366
The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic-resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. ...
3.
Bawankar P, Lence T, Paolantoni C, Haussmann I, Kazlauskiene M, Jacob D, et al.
Nat Commun . 2021 Jun; 12(1):3778. PMID: 34145251
N-methyladenosine (mA) is the most abundant internal modification on mRNA which influences most steps of mRNA metabolism and is involved in several biological functions. The E3 ubiquitin ligase Hakai was...
4.
Worpenberg L, Paolantoni C, Longhi S, Mulorz M, Lence T, Wessels H, et al.
EMBO J . 2021 Jan; 40(4):e104975. PMID: 33428246
N6-methyladenosine (m A) regulates a variety of physiological processes through modulation of RNA metabolism. This modification is particularly enriched in the nervous system of several species, and its dysregulation has...
5.
Werner S, Galliot A, Pichot F, Kemmer T, Marchand V, Sednev M, et al.
Nucleic Acids Res . 2020 Dec; 49(4):e23. PMID: 33313868
Methods for the detection of m6A by RNA-Seq technologies are increasingly sought after. We here present NOseq, a method to detect m6A residues in defined amplicons by virtue of their...
6.
Angelova M, Dimitrova D, Silva B, Marchand V, Jacquier C, Achour C, et al.
Nucleic Acids Res . 2020 Jan; 48(4):2050-2072. PMID: 31943105
2'-O-Methylation (Nm) represents one of the most common RNA modifications. Nm affects RNA structure and function with crucial roles in various RNA-mediated processes ranging from RNA silencing, translation, self versus...
7.
Lence T, Paolantoni C, Worpenberg L, Roignant J
Biochim Biophys Acta Gene Regul Mech . 2018 Nov; 1862(3):222-229. PMID: 30395944
The field of RNA modifications, so-called epitranscriptomics, has flourished over the past years owing to improvements of detection methods and the identification of important regulatory players. N6-methyladenosine (mA) is the...
8.
Angelova M, Dimitrova D, Dinges N, Lence T, Worpenberg L, Carre C, et al.
Front Bioeng Biotechnol . 2018 May; 6:46. PMID: 29707539
Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities...
9.
Knuckles P, Lence T, Haussmann I, Jacob D, Kreim N, Carl S, et al.
Genes Dev . 2018 Mar; 32(5-6):415-429. PMID: 29535189
-methyladenosine (mA) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. mA is catalyzed by the activity of methyltransferase-like 3 (Mettl3), which depends on...
10.
Rot G, Wang Z, Huppertz I, Modic M, Lence T, Hallegger M, et al.
Cell Rep . 2017 May; 19(5):1056-1067. PMID: 28467899
Many RNA-binding proteins (RBPs) regulate both alternative exons and poly(A) site selection. To understand their regulatory principles, we developed expressRNA, a web platform encompassing computational tools for integration of iCLIP...