Lina Worpenberg
Overview
Explore the profile of Lina Worpenberg including associated specialties, affiliations and a list of published articles.
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9
Citations
231
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Recent Articles
1.
Mattioli F, Worpenberg L, Li C, Ibrahim N, Naz S, Sharif S, et al.
Genet Med
. 2023 May;
25(9):100900.
PMID: 37226891
Purpose: 5-methylcytosine RNA modifications are driven by NSUN methyltransferases. Although variants in NSUN2 and NSUN3 were associated with neurodevelopmental diseases, the physiological role of NSUN6 modifications on transfer RNAs and...
2.
Worpenberg L, Paolantoni C, Roignant J
Bioessays
. 2021 Dec;
44(2):e2100174.
PMID: 34873719
RNA modifications have recently emerged as an important regulatory layer of gene expression. The most prevalent and reversible modification on messenger RNA (mRNA), N6-methyladenosine, regulates most steps of RNA metabolism...
3.
Worpenberg L, Paolantoni C, Longhi S, Mulorz M, Lence T, Wessels H, et al.
EMBO J
. 2021 Jan;
40(4):e104975.
PMID: 33428246
N6-methyladenosine (m A) regulates a variety of physiological processes through modulation of RNA metabolism. This modification is particularly enriched in the nervous system of several species, and its dysregulation has...
4.
Worpenberg L, Jakobi T, Dieterich C, Roignant J
Methods Mol Biol
. 2018 Dec;
1870:89-106.
PMID: 30539549
mA is the most abundant internal modification on mRNA. Recent improvements of high-throughput sequencing techniques enables its detection at the transcriptome level, even at the nucleotide resolution. However most current...
5.
Raoux-Barbot D, Belyy A, Worpenberg L, Montluc S, Deville C, Henriot V, et al.
PLoS One
. 2018 Nov;
13(11):e0206133.
PMID: 30419035
Several bacterial pathogens produce nucleotidyl cyclase toxins to manipulate eukaryotic host cells. Inside host cells they are activated by endogenous cofactors to produce high levels of cyclic nucleotides (cNMPs). The...
6.
Lence T, Paolantoni C, Worpenberg L, Roignant J
Biochim Biophys Acta Gene Regul Mech
. 2018 Nov;
1862(3):222-229.
PMID: 30395944
The field of RNA modifications, so-called epitranscriptomics, has flourished over the past years owing to improvements of detection methods and the identification of important regulatory players. N6-methyladenosine (mA) is the...
7.
Angelova M, Dimitrova D, Dinges N, Lence T, Worpenberg L, Carre C, et al.
Front Bioeng Biotechnol
. 2018 May;
6:46.
PMID: 29707539
Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities...
8.
Briest F, Grass I, Sedding D, Mobs M, Christen F, Benecke J, et al.
Neuroendocrinology
. 2017 Sep;
107(1):1-23.
PMID: 28910819
Background/aims: The tumor suppressor p53 is rarely mutated in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) but they frequently show a strong expression of negative regulators of p53, rendering these tumors excellent targets...
9.
Belyy A, Raoux-Barbot D, Saveanu C, Namane A, Ogryzko V, Worpenberg L, et al.
Nat Commun
. 2016 Dec;
7:13582.
PMID: 27917880
The nucleotidyl cyclase toxin ExoY is one of the virulence factors injected by the Pseudomonas aeruginosa type III secretion system into host cells. Inside cells, it is activated by an...