Timothy R Gershon
Overview
Explore the profile of Timothy R Gershon including associated specialties, affiliations and a list of published articles.
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39
Citations
1085
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Recent Articles
1.
Li Y, Lim C, Dismuke T, Malawsky D, Oasa S, Bruce Z, et al.
Nat Commun
. 2025 Feb;
16(1):1091.
PMID: 39904981
OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population. Here, we...
2.
Moertel C, Hirbe A, Shuhaiber H, Bielamowicz K, Sidhu A, Viskochil D, et al.
J Clin Oncol
. 2024 Nov;
43(6):716-729.
PMID: 39514826
Purpose: Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none are US Food and Drug Administration-approved for adults. Methods: ReNeu is an open-label, multicenter, pivotal, phase...
3.
Malawsky D, Dismuke T, Liu H, Castellino E, Brenman J, Dasgupta B, et al.
iScience
. 2023 Dec;
26(12):108443.
PMID: 38094249
We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist...
4.
Li Y, Lim C, Dismuke T, Malawsky D, Oasa S, Bruce Z, et al.
Res Sq
. 2023 Jun;
PMID: 37333134
Recurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated the anti-tumor potential of the small-molecule OLIG2 inhibitor...
5.
Kunhiraman H, McSwain L, Shahab S, Gershon T, MacDonald T, Kenney A
Acta Neuropathol Commun
. 2023 Apr;
11(1):62.
PMID: 37029430
Medulloblastoma (MB) is the most common pediatric brain malignancy and is divided into four molecularly distinct subgroups: WNT, Sonic Hedgehog (SHHp53mut and SHHp53wt), Group 3, and Group 4. Previous reports...
6.
Cleveland A, Malawsky D, Churiwal M, Rodriguez C, Reed F, Schniederjan M, et al.
Acta Neuropathol Commun
. 2023 Jan;
11(1):8.
PMID: 36635771
We show that Polycomb Repressive Complex-2 (PRC2) components EED and EZH2 maintain neural identity in cerebellar granule neuron progenitors (CGNPs) and SHH-driven medulloblastoma, a cancer of CGNPs. Proliferating CGNPs and...
7.
Malawsky D, Gershon T
Methods Mol Biol
. 2022 Nov;
2583:123-125.
PMID: 36418730
Analysis of single-cell RNA sequencing typically includes the clustering of cells and subsequent determination of the population size of each cluster, relative to the whole. In an experimental setting, two...
8.
De la Cruz G, Nikolaishvili-Feinberg N, Gershon T
Methods Mol Biol
. 2022 Nov;
2583:55-61.
PMID: 36418725
Neural progenitors show a strong tendency to undergo apoptosis in response to DNA damage, and both impaired DNA repair and increased neural progenitor apoptosis are associated with microcephaly. Here we...
9.
De la Cruz G, Nikolaishvili-Feinberg N, Williams S, Gershon T
Methods Mol Biol
. 2022 Nov;
2583:49-54.
PMID: 36418724
Analyzing sections of neonatal mouse brain using immunohistochemistry can inform microcephaly pathogenesis, but obtaining and staining high-quality sections can be challenging. The neonatal brain shows less structural integrity than the...
10.
Swiderska-Syn M, Mir-Pedrol J, Oles A, Schleuger O, Salvador A, Greiner S, et al.
Sci Adv
. 2022 Jul;
8(29):eabj9138.
PMID: 35857834
SRY (sex determining region Y)-box 2 (SOX2)-labeled cells play key roles in chemoresistance and tumor relapse; thus, it is critical to elucidate the mechanisms propagating them. Single-cell transcriptomic analyses of...