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Rajeev Vibhakar

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Articles 108
Citations 3846
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Recent Articles
1.
Galbraith K, Wu J, Sikkink K, Mohamed H, Reid D, Perez-Arreola M, et al.
J Mol Diagn . 2025 Mar; PMID: 40023492
Chromosomal structural variants (SVs) are major contributors to cancer development. Although multiple methods exist for detecting SVs, they are limited in throughput, such as fluorescent in situ hybridization and targeted...
2.
Alimova I, Wang D, DeSisto J, Danis E, Lakshmanachetty S, Prince E, et al.
Mol Cancer Res . 2025 Feb; PMID: 39960392
Atypical teratoid rhabdoid tumor (ATRT) is a highly aggressive pediatric brain tumor driven by the loss of SMARCB1, which results in epigenetic dysregulation of the genome. SMARCB1 loss affects lineage...
3.
de Sousa G, Calzadilla A, Grimaldo E, Donson A, Sobral L, Jones K, et al.
Neuro Oncol . 2025 Feb; PMID: 39901723
Background: Posterior fossa molecular subtype A (PFA) ependymoma occurs in young children and is the deadliest subtype of pediatric ependymoma. High-risk subtypes with chromosome 1q+ and/or 6q- exhibit significantly poorer...
4.
Veo B, Wang D, DeSisto J, Pierce A, Vibhakar R
Res Sq . 2024 Dec; PMID: 39711559
Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, exhibiting clinical and genomic heterogeneity. Of the four major subgroups, Group 3 tumors (MYC-MB), display high levels of MYC...
5.
Wang D, Ritz C, Pierce A, Veo B, Luo Y, Brunt B, et al.
Res Sq . 2024 Nov; PMID: 39574899
MYC-driven medulloblastoma (MB) is a highly aggressive cancer type with poor prognosis and limited treatment options. Through CRISPR-Cas9 screening of MB cell lines, we identified the Mediator-associated kinase CDK8 as...
6.
DeSisto J, Balakrishnan I, Knox A, Link G, Venkataraman S, Vibhakar R, et al.
Mol Cancer Res . 2024 Oct; 23(2):107-118. PMID: 39422546
Pediatric high-grade gliomas (PHGG) are aggressive, undifferentiated central nervous system tumors with poor outcomes, for which no standard-of-care drug therapy currently exists. Through a knockdown (KD) screen for epigenetic regulators,...
7.
Raybin J, Donson A, Foreman N, Vibhakar R, Handler M, Liu A
J Adv Pract Oncol . 2024 Jul; 15(1):28-35. PMID: 39055368
Purpose: Oncology advanced practitioners (APs) are on the front line in treating adverse effects. Among children with brain tumors, treatments such as craniospinal irradiation (CSI) cause neurocognitive injury, endocrinopathies, and...
8.
Rodriguez-Blanco J, Salvador A, Suter R, Swiderska-Syn M, Palomo-Caturla I, Kliebe V, et al.
J Clin Invest . 2024 Jun; 134(15). PMID: 38885332
Most children with medulloblastoma (MB) achieve remission, but some face very aggressive metastatic tumors. Their dismal outcome highlights the critical need to advance therapeutic approaches that benefit such high-risk patients....
9.
Walker F, Sobral L, Danis E, Sanford B, Donthula S, Balakrishnan I, et al.
Nat Commun . 2024 May; 15(1):4616. PMID: 38816355
Dynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. P-TEFb-mediated pause-release of RNA polymerase II (Pol II) is a conserved regulatory mechanism for synchronous transcriptional induction...
10.
Zahedi S, Riemondy K, Griesinger A, Donson A, Fu R, Crespo M, et al.
bioRxiv . 2024 Apr; PMID: 38645202
Key Points: There is a developmental hierarchy in neoplastic population comprising of both progenitor-like and mature cell types in both PA and GG.A more immunogenic, immune activating myeloid population is...