Timothy R Dafforn
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Explore the profile of Timothy R Dafforn including associated specialties, affiliations and a list of published articles.
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83
Citations
1667
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Recent Articles
1.
Kuyler G, Barnard E, Sridhar P, Murray R, Pollock N, Wheatley M, et al.
Biomacromolecules
. 2024 Dec;
26(1):415-427.
PMID: 39725644
Membrane proteins (MPs) are critical to cellular processes and serve as essential therapeutic targets. However, their isolation and characterization are often impeded by traditional detergent-based methods, which can compromise their...
2.
Li H, Pike A, Lotsaris I, Chi G, Hansen J, Lee S, et al.
Nat Commun
. 2024 Jul;
15(1):5503.
PMID: 38951531
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and...
3.
Little H, Ali A, Carter J, Hicks M, Dafforn T, Tucker J
Front Chem
. 2023 May;
11:1040873.
PMID: 37228864
A plug-and-play sandwich assay platform for the aptamer-based detection of molecular targets using linear dichroism (LD) spectroscopy as a read-out method has been demonstrated. A 21-mer DNA strand comprising the...
4.
Martin A, Jemmett P, Howitt T, Wood M, Burley A, Cox L, et al.
Langmuir
. 2023 Feb;
39(7):2676-2691.
PMID: 36757323
The effect of lipid composition on models of the inner leaflet of mammalian cell membranes has been investigated. Grazing incidence X-ray diffraction and X-ray and neutron reflectivity have been used...
5.
Jemmett P, Milan D, Nichols R, Howitt T, Martin A, Arnold T, et al.
Langmuir
. 2022 Nov;
38(46):14290-14301.
PMID: 36354380
Sphingolipids are an important class of lipids found in mammalian cell membranes with important structural and signaling roles. They differ from another major group of lipids, the glycerophospholipids, in the...
6.
Passaretti P, Sun Y, Dafforn T, Goldberg Oppenheimer P
RSC Adv
. 2022 May;
10(42):25385-25392.
PMID: 35517472
To truly understand the mechanisms behind the supramolecular self-assembly of nanocomponents, the characterisation of their surface properties is crucial. M13 emerged as a practical nanocomponent for bio-nanoassemblies of functional materials...
7.
Pollock N, Lloyd J, Montinaro C, Rai M, Dafforn T
Biochem J
. 2022 Jan;
479(2):145-159.
PMID: 35050326
ATP-binding cassette (ABC) proteins play important roles in cells as importers and exporters but as membrane proteins they are subject to well-known challenges of isolating pure and stable samples for...
8.
Carter J, Pfukwa R, Riley L, Tucker J, Rodger A, Dafforn T, et al.
ACS Omega
. 2021 Dec;
6(48):33231-33237.
PMID: 34901675
Controllable higher-order assembly is a central aim of macromolecular chemistry. An essential challenge to developing these molecules is improving our understanding of the structures they adopt under different conditions. Here,...
9.
Hawkins O, Jahromi C, Gulamhussein A, Nestorow S, Bahra T, Shelton C, et al.
Biochim Biophys Acta Biomembr
. 2021 Sep;
1863(12):183758.
PMID: 34480878
Styrene maleic acid (SMA) polymers have proven to be very successful for the extraction of membrane proteins, forming SMA lipid particles (SMALPs), which maintain a lipid bilayer around the membrane...
10.
Ali A, Little H, Carter J, Douglas C, Hicks M, Kenyon D, et al.
RSC Chem Biol
. 2021 Aug;
1(5):449-454.
PMID: 34458772
Nucleic acid detection is an important part of our bio-detection arsenal, with the COVID-19 pandemic clearly demonstrating the importance to healthcare of rapid and efficient detection of specific pathogenic sequences....