Jonathan Wanagat
Overview
Explore the profile of Jonathan Wanagat including associated specialties, affiliations and a list of published articles.
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45
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1245
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Recent Articles
1.
Vandiver A, Torres Jr A, Sanden A, Nguyen T, Gasilla J, Doan M, et al.
Aging Cell
. 2024 Dec;
24(3):e14402.
PMID: 39680477
The mitochondrial genome (mtDNA) is an important source of inherited extranuclear variation. Clonal increases in mtDNA mutation heteroplasmy have been implicated in aging and disease, although the impact of this...
2.
Vandiver A, Herbst A, Stothard P, Wanagat J
Genome Res
. 2024 Nov;
35(1):55-65.
PMID: 39603705
Although it is well understood that mitochondrial DNA (mtDNA) deletion mutations cause incurable diseases and contribute to aging, little is known about the transcriptional products that arise from these DNA...
3.
Musci R, Fuqua J, Peelor 3rd F, Nguyen H, Richardson A, Choi S, et al.
Geroscience
. 2024 Sep;
47(1):851-862.
PMID: 39312152
Mitochondrial genomic integrity is a key element of physiological processes and health. Changes in the half-life of the mitochondrial genome are implicated in the generation and accumulation of age-induced mitochondrial...
4.
Mello M, Lockwood T, Wanagat J, Westerhausen M, Bishop D
J Anal At Spectrom
. 2024 Sep;
39(7):1720-1725.
PMID: 39220150
Elemental bioimaging of low abundant elements via laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS) is hampered by a lack of sensitivity. Novel solutions for specific applications have been developed, however...
5.
Zhou Z, Ma A, Moore T, Wolf D, Yang N, Tran P, et al.
Sci Adv
. 2024 Apr;
10(14):eadl0389.
PMID: 38569044
The dynamin-related guanosine triphosphatase, Drp1 (encoded by ), plays a central role in mitochondrial fission and is requisite for numerous cellular processes; however, its role in muscle metabolism remains unclear....
6.
Mello M, Westerhausen M, Lockwood T, Singh P, Wanagat J, Bishop D
Anal Bioanal Chem
. 2023 Oct;
416(11):2725-2735.
PMID: 37801117
Immuno-mass spectrometry imaging uses lanthanide-conjugated antibodies to spatially quantify biomolecules via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). The multi-element capabilities allow for highly multiplexed analyses that may include both conjugated...
7.
Vandiver A, Hoang A, Herbst A, Lee C, Aiken J, McKenzie D, et al.
Aging Cell
. 2023 May;
22(6):e13842.
PMID: 37132288
Mitochondrial DNA (mtDNA) deletion mutations cause many human diseases and are linked to age-induced mitochondrial dysfunction. Mapping the mutation spectrum and quantifying mtDNA deletion mutation frequency is challenging with next-generation...
8.
Sathiaseelan R, Ahn B, Stout M, Logan S, Wanagat J, Nguyen H, et al.
J Gerontol A Biol Sci Med Sci
. 2023 Feb;
78(5):771-779.
PMID: 36762848
We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide...
9.
Herbst A, Choi S, Hoang A, Kim C, Martinez Moreno D, McKenzie D, et al.
PLoS One
. 2022 Oct;
17(10):e0271850.
PMID: 36288327
Remdesivir is a leading therapy in patients with moderate to severe coronavirus 2 (SARS-CoV-2) infection; the majority of whom are older individuals. Remdesivir is a nucleoside analog that incorporates into...
10.
Herbst A, Aiken J, Kim C, Gushue D, McKenzie D, Moore T, et al.
Geroscience
. 2022 Sep;
45(1):555-567.
PMID: 36178599
Beta-guanidinopropionic acid (GPA) is a creatine analog suggested as a treatment for hypertension, diabetes, and obesity, which manifest primarily in older adults. A notable side effect of GPA is the...