Timothy J Ragan
Overview
Explore the profile of Timothy J Ragan including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
658
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0
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Recent Articles
1.
Kwong H, Paloni M, Grandvuillemin L, Sirounian S, Ancelin A, Lai-Kee-Him J, et al.
J Mol Biol
. 2023 Dec;
436(3):168411.
PMID: 38135181
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor belonging to the bHLH/PAS protein family and responding to hundreds of natural and chemical substances. It is primarily involved in...
2.
Wang S, Fairall L, Pham T, Ragan T, Vashi D, Collins M, et al.
Nucleic Acids Res
. 2023 Apr;
51(12):6006-6019.
PMID: 37099381
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues...
3.
Ragan T, Vincent H
Methods Mol Biol
. 2023 Feb;
2633:65-79.
PMID: 36853457
The ability to enzymatically assemble DNA oligonucleotides into longer DNA duplexes in a process known as gene synthesis has wide-ranging applications in the fields of genetic engineering and synthetic biology....
4.
Brotherton D, Savva C, Ragan T, Dale N, Cameron A
Structure
. 2022 Mar;
30(5):697-706.e4.
PMID: 35276081
Connexins form large-pore channels that function either as dodecameric gap junctions or hexameric hemichannels to allow the regulated movement of small molecules and ions across cell membranes. Opening or closing...
5.
Lancey C, Tehseen M, Bakshi S, Percival M, Takahashi M, Sobhy M, et al.
Nat Commun
. 2021 Oct;
12(1):6095.
PMID: 34667155
Y-family DNA polymerase κ (Pol κ) can replicate damaged DNA templates to rescue stalled replication forks. Access of Pol κ to DNA damage sites is facilitated by its interaction with...
6.
Fox J, Hughes M, Meng X, Sarnowska N, Powley I, Jukes-Jones R, et al.
Nat Commun
. 2021 Feb;
12(1):819.
PMID: 33547302
Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its regulatory partners,...
7.
Millard C, Fairall L, Ragan T, Savva C, Schwabe J
Nucleic Acids Res
. 2020 Dec;
48(22):12972-12982.
PMID: 33264408
Class I histone deacetylase complexes play essential roles in many nuclear processes. Whilst they contain a common catalytic subunit, they have diverse modes of action determined by associated factors in...
8.
Mureddu L, Ragan T, Brooksbank E, Vuister G
J Biomol NMR
. 2020 Jul;
74(10-11):565-577.
PMID: 32638146
Fragment-based drug discovery or FBDD is one of the main methods used by industry and academia for identifying drug-like candidates in early stages of drug discovery. NMR has a significant...
9.
Lancey C, Tehseen M, Raducanu V, Rashid F, Merino N, Ragan T, et al.
Nat Commun
. 2020 Mar;
11(1):1109.
PMID: 32111820
In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki...
10.
Fets L, Driscoll P, Grimm F, Jain A, Nunes P, Gounis M, et al.
Nat Chem Biol
. 2019 Oct;
15(12):1249.
PMID: 31645751
An amendment to this paper has been published and can be accessed via a link at the top of the paper.