Louise Fairall
Overview
Explore the profile of Louise Fairall including associated specialties, affiliations and a list of published articles.
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44
Citations
2493
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Recent Articles
1.
Whedon S, Lee K, Wang Z, Zahn E, Lu C, Yapa Abeywardana M, et al.
J Am Chem Soc
. 2024 Nov;
146(49):33914-33927.
PMID: 39585806
Reversible modification of the histone H3 N-terminal tail is critical in regulating the chromatin structure, gene expression, and cell states, while its dysregulation contributes to disease pathogenesis. Understanding the crosstalk...
2.
Whedon S, Lee K, Wang Z, Zahn E, Lu C, Yapa-Abeywardana M, et al.
bioRxiv
. 2024 Oct;
PMID: 39372790
Reversible modification of the histone H3 N-terminal tail is critical in regulating chromatin structure, gene expression, and cell states, while its dysregulation contributes to disease pathogenesis. Understanding the crosstalk between...
3.
Ferrari A, Whang E, Xiao X, Kennelly J, Romartinez-Alonso B, Mack J, et al.
Science
. 2023 Nov;
382(6671):eadf0966.
PMID: 37943936
Intestinal absorption is an important contributor to systemic cholesterol homeostasis. Niemann-Pick C1 Like 1 (NPC1L1) assists in the initial step of dietary cholesterol uptake, but how cholesterol moves downstream of...
4.
Tariq M, Ikeya T, Togashi N, Fairall L, Kamei S, Mayooramurugan S, et al.
Life Sci Alliance
. 2023 Oct;
7(1).
PMID: 37833074
About a quarter of total human cancers carry mutations in Ras isoforms. Accumulating evidence suggests that small GTPases, RalA, and RalB, and their activators, Ral guanine nucleotide exchange factors (RalGEFs),...
5.
Ferrari A, Whang E, Xiao X, Kennelly J, Romartinez-Alonso B, Mack J, et al.
bioRxiv
. 2023 Jul;
PMID: 37503112
One-sentence Summary: Identification of a targetable pathway for regulation of dietary cholesterol absorption.
6.
Wang S, Fairall L, Pham T, Ragan T, Vashi D, Collins M, et al.
Nucleic Acids Res
. 2023 Apr;
51(12):6006-6019.
PMID: 37099381
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues...
7.
Wang Z, Whedon S, Wu M, Wang S, Brown E, Anmangandla A, et al.
J Am Chem Soc
. 2022 Feb;
144(8):3360-3364.
PMID: 35175758
We describe a new method to produce histone H2B by semisynthesis with an engineered sortase transpeptidase. N-Terminal tail site-specifically modified acetylated, lactylated, and β-hydroxybutyrylated histone H2Bs were incorporated into nucleosomes...
8.
Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α
Romartinez-Alonso B, Agostini M, Jones H, McLellan J, Sood D, Tomkinson N, et al.
Mol Cell Biol
. 2021 Dec;
42(2):e0036321.
PMID: 34871063
Mutations in thyroid hormone receptor α (TRα), a ligand-inducible transcription factor, cause resistance to thyroid hormone α (RTHα). This disorder is characterized by tissue-specific hormone refractoriness and hypothyroidism due to...
9.
Fox J, Hughes M, Meng X, Sarnowska N, Powley I, Jukes-Jones R, et al.
Nat Commun
. 2021 Feb;
12(1):819.
PMID: 33547302
Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its regulatory partners,...
10.
Millard C, Fairall L, Ragan T, Savva C, Schwabe J
Nucleic Acids Res
. 2020 Dec;
48(22):12972-12982.
PMID: 33264408
Class I histone deacetylase complexes play essential roles in many nuclear processes. Whilst they contain a common catalytic subunit, they have diverse modes of action determined by associated factors in...