Timothy E Vanderleest
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Explore the profile of Timothy E Vanderleest including associated specialties, affiliations and a list of published articles.
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10
Citations
131
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Recent Articles
1.
Linvill K, Russell L, Vanderleest T, Miao H, Xie Y, Blankenship J, et al.
J Cell Biol
. 2025 Jan;
224(4.
PMID: 39846952
In the early Drosophila embryo, germband elongation is driven by oriented cell intercalation through t1 transitions, where vertical (dorsal-ventral aligned) interfaces contract and then resolve into new horizontal (anterior-posterior aligned)...
2.
OHare M, Miller W, Arevalo-Alquichire S, Amarnani D, Apryani E, Perez-Corredor P, et al.
Sci Transl Med
. 2024 Nov;
16(775):eadh0994.
PMID: 39602510
Messenger RNA (mRNA)-based therapies are a promising approach to medical treatment. Except for infectious diseases, no other disease has mRNA-based therapies available. The eye is an ideal model for mRNA...
3.
Vanderleest T, Xie Y, Budhathoki R, Linvill K, Hobson C, Heddleston J, et al.
Curr Biol
. 2024 Jul;
34(14):3165-3177.e3.
PMID: 38959881
How pulsed contractile dynamics drive the remodeling of cell and tissue topologies in epithelial sheets has been a key question in development and disease. Due to constraints in imaging and...
4.
Perez-Corredor P, Vanderleest T, Vacano G, Sanchez J, Villalba-Moreno N, Marino C, et al.
Front Mol Neurosci
. 2024 Apr;
17:1373568.
PMID: 38571814
A patient with the E280A mutation and homozygous for Christchurch () displayed extreme resistance to Alzheimer's disease (AD) cognitive decline and tauopathy, despite having a high amyloid burden. To further...
5.
Marino C, Perez-Corredor P, OHare M, Heuer A, Chmielewska N, Gordon H, et al.
Alzheimers Dement
. 2023 Oct;
20(2):819-836.
PMID: 37791598
Introduction: We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer's disease (AD). This resistance may be due to reduced pathological interactions between ApoE3Ch and heparan sulfate...
6.
Vanderleest T, Xie Y, Smits C, Blankenship J, Loerke D
Mol Biol Cell
. 2022 Sep;
33(14):ar142.
PMID: 36129772
In the early embryo, the elongation of the anterior-posterior (AP) body axis is driven by cell intercalation in the germband epithelium. Neighboring cells intercalate through the contraction of AP interfaces...
7.
Miao H, Vanderleest T, Budhathoki R, Loerke D, Blankenship J
Dev Cell
. 2021 Sep;
56(18):2579-2591.e4.
PMID: 34525342
Force generation in epithelial tissues is often pulsatile, with actomyosin networks generating contractile forces before cyclically disassembling. This pulsed nature of cytoskeletal forces implies that there must be ratcheting mechanisms...
8.
Miao H, Vanderleest T, Jewett C, Loerke D, Blankenship J
J Cell Biol
. 2019 Sep;
218(11):3845-3860.
PMID: 31562231
During gastrulation, the invagination of the prospective mesoderm is driven by the pulsed constriction of apical surfaces. Here, we address the mechanisms by which the irreversibility of pulsed events is...
9.
Vanderleest T, Smits C, Xie Y, Jewett C, Blankenship J, Loerke D
Elife
. 2018 Jul;
7.
PMID: 29985789
Oriented cell intercalation is an essential developmental process that shapes tissue morphologies through the directional insertion of cells between their neighbors. Previous research has focused on properties of cellcell ,...
10.
Jewett C, Vanderleest T, Miao H, Xie Y, Madhu R, Loerke D, et al.
Nat Commun
. 2017 Sep;
8(1):476.
PMID: 28883443
The coordination between membrane trafficking and actomyosin networks is essential to the regulation of cell and tissue shape. Here, we examine Rab protein distributions during Drosophila epithelial tissue remodeling and...