Michael OHare
Overview
Explore the profile of Michael OHare including associated specialties, affiliations and a list of published articles.
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29
Citations
838
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Recent Articles
1.
OHare M, Miller W, Arevalo-Alquichire S, Amarnani D, Apryani E, Perez-Corredor P, et al.
Sci Transl Med
. 2024 Nov;
16(775):eadh0994.
PMID: 39602510
Messenger RNA (mRNA)-based therapies are a promising approach to medical treatment. Except for infectious diseases, no other disease has mRNA-based therapies available. The eye is an ideal model for mRNA...
2.
Marino C, Perez-Corredor P, OHare M, Heuer A, Chmielewska N, Gordon H, et al.
Alzheimers Dement
. 2023 Oct;
20(2):819-836.
PMID: 37791598
Introduction: We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer's disease (AD). This resistance may be due to reduced pathological interactions between ApoE3Ch and heparan sulfate...
3.
Lopera F, Marino C, Chandrahas A, OHare M, Villalba-Moreno N, Aguillon D, et al.
Nat Med
. 2023 May;
29(5):1243-1252.
PMID: 37188781
We characterized the world's second case with ascertained extreme resilience to autosomal dominant Alzheimer's disease (ADAD). Side-by-side comparisons of this male case and the previously reported female case with ADAD...
4.
OHare M, Esquiva G, McGahon M, Hombrebueno J, Augustine J, Canning P, et al.
JCI Insight
. 2022 Sep;
7(18).
PMID: 36134661
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the...
5.
OHare M, Arboleda-Velasquez J
Cold Spring Harb Perspect Med
. 2022 May;
PMID: 35534207
The Notch signaling pathway is a highly versatile and evolutionarily conserved mechanism with an important role in cell fate determination. Notch signaling plays a vital role in vascular development, regulating...
6.
OHare M, Amarnani D, Whitmore H, An M, Marino C, Ramos L, et al.
Am J Pathol
. 2021 Apr;
191(7):1193-1208.
PMID: 33894177
Pulmonary fibrosis (PF) can arise from unknown causes, as in idiopathic PF, or as a consequence of infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current treatments for PF...
7.
Gonzalez-Buendia L, Delgado-Tirado S, An M, OHare M, Amarnani D, Whitmore H, et al.
Am J Pathol
. 2020 Dec;
191(3):418-424.
PMID: 33345998
Choroidal neovascularization (CNV) is a prevalent cause of vision loss in patients with age-related macular degeneration. Runt-related transcription factor 1 (RUNX1) has been identified as an important mediator of aberrant...
8.
Whitmore H, Amarnani D, OHare M, Delgado-Tirado S, Gonzalez-Buendia L, An M, et al.
FASEB J
. 2020 Nov;
35(2):e21155.
PMID: 33135824
Runt-related transcription factor 1 (RUNX1) acts as a mediator of aberrant retinal angiogenesis and has been implicated in the progression of proliferative diabetic retinopathy (PDR). Patients with PDR, retinopathy of...
9.
Arboleda-Velasquez J, Lopera F, OHare M, Delgado-Tirado S, Marino C, Chmielewska N, et al.
Nat Med
. 2019 Nov;
25(11):1680-1683.
PMID: 31686034
We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after...
10.
ONeill K, Campbell D, Edgar K, Gill E, Moez A, McLoughlin K, et al.
Cardiovasc Res
. 2019 Apr;
116(2):393-405.
PMID: 30937452
Aims: Cord blood-derived endothelial colony-forming cells (CB-ECFCs) are a defined progenitor population with established roles in vascular homeostasis and angiogenesis, which possess low immunogenicity and high potential for allogeneic therapy...