Timothy E Sweeney
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Explore the profile of Timothy E Sweeney including associated specialties, affiliations and a list of published articles.
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81
Citations
2636
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Recent Articles
1.
Lu J, Ter Voert M, Unal M, Whitfield N, Liesenfeld O, Ter Maaten J, et al.
Intensive Care Med Exp
. 2025 Feb;
13(1):21.
PMID: 39982589
Background: Early sepsis diagnosis is essential to allow timely initiation of adequate care. The TriVerity™ Test, performed on the Myrna™ Instrument, is the first rapid high-multiplex host-response mRNA diagnostic test...
2.
de Brabander J, Michels E, Butler J, Reijnders T, van Engelen T, Leite G, et al.
Eur Respir J
. 2025 Jan;
PMID: 39848701
Introduction: Immune response dysregulation has been implicated in the development of intensive care unit (ICU)-acquired pneumonia. We aimed to determine differences in the longitudinal blood transcriptional response between patients who...
3.
Moore A, Zheng H, Ganesan A, Hasin-Brumshtein Y, Maddali M, Levitt J, et al.
bioRxiv
. 2024 Nov;
PMID: 39605502
Progress in the management of critical care syndromes such as sepsis, Acute Respiratory Distress Syndrome (ARDS), and trauma has slowed over the last two decades, limited by the inherent heterogeneity...
4.
Atreya M, Huang M, Moore A, Zheng H, Hasin-Brumshtein Y, Fitzgerald J, et al.
Crit Care
. 2024 Jul;
28(1):246.
PMID: 39014377
Background: Sepsis poses a grave threat, especially among children, but treatments are limited owing to heterogeneity among patients. We sought to test the clinical and biological relevance of pediatric septic...
5.
Leite G, de Brabander J, Michels E, Butler J, Cremer O, Scicluna B, et al.
Crit Care
. 2024 Mar;
28(1):88.
PMID: 38504349
Background: Sepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing investigations identified an immature bone-marrow-derived CD14 monocyte phenotype with immune suppressive properties...
6.
Kyriazopoulou E, Hasin-Brumshtein Y, Midic U, Poulakou G, Milionis H, Metallidis S, et al.
Crit Care
. 2024 Mar;
28(1):73.
PMID: 38475786
Background: Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human interleukin 1...
7.
Atreya M, Huang M, Moore A, Zheng H, Hasin-Brumshtein Y, Fitzgerald J, et al.
Res Sq
. 2023 Dec;
PMID: 38105983
Background: Sepsis poses a grave threat, especially among children, but treatments are limited due to clinical and biological heterogeneity among patients. Thus, there is an urgent need for precise subclassification...
8.
Pandya R, He Y, Sweeney T, Hasin-Brumshtein Y, Khatri P
Genome Med
. 2023 Aug;
15(1):64.
PMID: 37641125
Background: Viral acute respiratory illnesses (viral ARIs) contribute significantly to human morbidity and mortality worldwide, but their successful treatment requires timely diagnosis of viral etiology, which is complicated by overlap...
9.
Balch J, Chen U, Liesenfeld O, Starostik P, Loftus T, Efron P, et al.
Crit Care
. 2023 Jul;
27(1):292.
PMID: 37474944
Background: Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated whether patients admitted...
10.
Balch J, Chen U, Liesenfeld O, Starostik P, Loftus T, Efron P, et al.
Res Sq
. 2023 May;
PMID: 37214996
Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying characteristic gene expression patterns, or endotypes, in septic patients may lead to targeted interventions. We investigated whether patients admitted to...