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James Wacker

Explore the profile of James Wacker including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 9
Citations 133
Followers 0
Related Specialties
General Medicine
Critical Care
Emergency Medicine
Top 10 Co-Authors
Timothy E Sweeney
Oliver Liesenfeld
Uros Midic
Ljubomir Buturovic
Roland Luethy
Melissa Remmel
David Rawling
Rajan Somasundaram
Rudolf Tauber
Philip A Efron
Published In
Crit Care Med
Nat Commun
S D Med
Eur J Emerg Med
Crit Care Explor
Affiliations
Soon will be listed here.
Recent Articles
1.
Expression Patterns of DLL3 across Neuroendocrine and Non-neuroendocrine Neoplasms Reveal Broad Opportunities for Therapeutic Targeting
Lozada J, Elliott A, Evans M, Wacker J, Storey K, Egusa E, et al.
Cancer Res Commun . 2025 Jan; 5(2):318-326. PMID: 39874041
DLL3-targeted therapies have recently shown robust clinical efficacy in aggressive neuroendocrine cancers, positioning them to fulfill a great unmet need in these settings. Here, we examine the clinical and biological...
2.
Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients
Brakenridge S, Chen U, Loftus T, Ungaro R, Dirain M, Kerr A, et al.
JAMA Netw Open . 2022 Jul; 5(7):e2221520. PMID: 35819783
Importance: Rapid and accurate discrimination of sepsis and its potential severity currently require multiple assays with slow processing times that are often inconclusive in discerning sepsis from sterile inflammation. Objective:...
3.
Prospective validation of a transcriptomic severity classifier among patients with suspected acute infection and sepsis in the emergency department
Galtung N, Diehl-Wiesenecker E, Lehmann D, Markmann N, Bergstrom W, Wacker J, et al.
Eur J Emerg Med . 2022 Apr; 29(5):357-365. PMID: 35467566
Background And Importance: mRNA-based host response signatures have been reported to improve sepsis diagnostics. Meanwhile, prognostic markers for the rapid and accurate prediction of severity in patients with suspected acute...
4.
A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections
Buturovic L, Zheng H, Tang B, Lai K, Kuan W, Gillett M, et al.
Sci Rep . 2022 Jan; 12(1):889. PMID: 35042868
Predicting the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent...
5.
A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients
Brakenridge S, Starostik P, Ghita G, Midic U, Darden D, Fenner B, et al.
Crit Care Explor . 2021 Oct; 3(10):e0554. PMID: 34671746
Objectives: Clinically deployable methods for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice are currently lacking. We evaluated a whole-blood, multiplex...
6.
A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study
Bauer W, Kappert K, Galtung N, Lehmann D, Wacker J, Cheng H, et al.
Crit Care Med . 2021 Jun; 49(10):1664-1673. PMID: 34166284
Objectives: The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for suspected sepsis patients to...
7.
Short-term Cost Comparison of Systemic Heparin Therapy vs. Catheter Directed Thrombolysis for the Treatment of Massive and Submassive Pulmonary Embolism with Long-Term Chronic Pulmonary Hypertension Cost Model
Johnson K, VandenHull A, Remund T, Pohlson K, Bares V, Wacker J, et al.
S D Med . 2021 Jun; 74(2):70-74. PMID: 34161687
Introduction: Pulmonary embolism (PE) is a significant disease process that affects an estimated 117 cases per 100,000 person-years. Chronic pulmonary hypertension (CPH) is a long-term complication associated with acute PE...
8.
A host transcriptomic signature for identification of respiratory viral infections in the community
Almansa R, Herrero-Rodriguez C, Martinez-Huelamo M, Vicente-Andres M, Nieto-Barbero J, Martin-Ballesteros M, et al.
Eur J Clin Invest . 2021 Jun; 51(12):e13626. PMID: 34120332
Background: Fever-7 is a test evaluating host mRNA expression levels of IFI27, JUP, LAX, HK3, TNIP1, GPAA1 and CTSB in blood able to detect viral infections. This test has been...
9.
Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019
Sweeney T, Liesenfeld O, Wacker J, He Y, Rawling D, Remmel M, et al.
Crit Care Med . 2020 Nov; 49(2):e170-e178. PMID: 33201004
Objectives: Complex critical syndromes like sepsis and coronavirus disease 2019 may be composed of underling "endotypes," which may respond differently to treatment. The aim of this study was to test...
10.
A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections
Mayhew M, Buturovic L, Luethy R, Midic U, Moore A, Roque J, et al.
Nat Commun . 2020 Mar; 11(1):1177. PMID: 32132525
Improved identification of bacterial and viral infections would reduce morbidity from sepsis, reduce antibiotic overuse, and lower healthcare costs. Here, we develop a generalizable host-gene-expression-based classifier for acute bacterial and...