Timothy B Ware
Overview
Explore the profile of Timothy B Ware including associated specialties, affiliations and a list of published articles.
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11
Citations
114
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Recent Articles
1.
Sharma H, Bielecki M, Holm M, Thompson T, Yin Y, Cravatt J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975370
Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds ('stereoprobes') offers a versatile way to discover covalent ligands for proteins in native biological systems. Here we report the...
2.
Tang I, Nisal A, Reed A, Ware T, Johansen A, Zaki M, et al.
Sci Transl Med
. 2025 Jan;
17(779):eadp5247.
PMID: 39742503
Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder, including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase signaling. encodes a key acyltransferase in PI synthesis and...
3.
Chen M, Shin M, Ware T, Donvito G, Muchhala K, Mischel R, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(52):e2304900120.
PMID: 38109529
Diacylglycerol lipase-beta (DAGLβ) serves as a principal 2-arachidonoylglycerol (2-AG) biosynthetic enzyme regulating endocannabinoid and eicosanoid metabolism in immune cells including macrophages and dendritic cells. Genetic or pharmacological inactivation of DAGLβ...
4.
Ozturk H, Cingoz H, Tufan T, Yang J, Adair S, Tummala K, et al.
Dev Cell
. 2022 May;
57(11):1331-1346.e9.
PMID: 35508175
Pancreatic ductal adenocarcinoma (PDA) cells reprogram their transcriptional and metabolic programs to survive the nutrient-poor tumor microenvironment. Through in vivo CRISPR screening, we discovered islet-2 (ISL2) as a candidate tumor...
5.
Hussain S, Tran T, Ware T, Luse M, Prevost C, Ferguson A, et al.
Cell Rep
. 2021 Jul;
36(4):109451.
PMID: 34320341
Lipid droplets (LDs) are dynamic organelles that undergo dynamic changes in response to changing cellular conditions. During nutrient depletion, LD numbers increase to protect cells against toxic fatty acids generated...
6.
Ware T, Hsu K
Curr Opin Chem Biol
. 2021 Jul;
65:101-108.
PMID: 34311404
Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments...
7.
Nass S, Steele F, Ware T, Libby A, Hsu K, Kinsey S
Cannabis Cannabinoid Res
. 2021 May;
6(3):233-241.
PMID: 34042520
Patients with rheumatoid arthritis (RA) experience joint swelling and cartilage destruction resulting in chronic pain, functional disability, and compromised joint function. Current RA treatments, including glucocorticoid receptor agonists, produce adverse...
8.
Shin M, Ware T, Hsu K
Cell Chem Biol
. 2020 Jan;
27(3):314-321.e5.
PMID: 31991095
Here, we apply quantitative chemical proteomics and untargeted lipidomics to assign a polyunsaturated fatty acid (PUFA)-specific triacylglycerol (TAG) lipase activity for diacylglycerol lipase-beta (DAGLβ) in macrophages. We demonstrate that DAGLβ...
9.
Ware T, Franks C, Granade M, Zhang M, Kim K, Park K, et al.
Nat Chem Biol
. 2020 Jan;
16(2):170-178.
PMID: 31932721
C1 domains are lipid-binding modules that regulate membrane activation of kinases, nucleotide exchange factors and other C1-containing proteins to trigger signal transduction. Despite annotation of typical C1 domains as diacylglycerol...
10.
Hahm H, Toroitich E, Borne A, Brulet J, Libby A, Yuan K, et al.
Nat Chem Biol
. 2019 Nov;
16(2):150-159.
PMID: 31768034
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g., cysteine and...