Timothy A J Haystead
Overview
Explore the profile of Timothy A J Haystead including associated specialties, affiliations and a list of published articles.
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Articles
58
Citations
1425
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Recent Articles
1.
Al-Ghabkari A, Carlson D, Haystead T, MacDonald J
bioRxiv
. 2024 Mar;
PMID: 38496458
Zipper-interacting protein kinase (ZIPK) is a Ser/Thr protein kinase with regulatory involvement in vascular smooth muscle cell (VSMC) actin polymerization and focal adhesion assembly dynamics. ZIPK silencing can induce cytoskeletal...
2.
Mansfield C, Quan B, Chirgwin M, Eduful B, Hughes P, Neveu G, et al.
Cell Chem Biol
. 2024 Mar;
31(4):729-742.e13.
PMID: 38492573
The molecular chaperone heat shock protein 90 (Hsp90) has an essential but largely undefined role in maintaining proteostasis in Plasmodium falciparum, the most lethal malaria parasite. Herein, we identify BX-2819...
3.
Carlson D, Kowalewski M, Bodoor K, Lietzan A, Hughes P, Gooden D, et al.
Cell Chem Biol
. 2023 Nov;
31(3):465-476.e12.
PMID: 37918401
Conventional antimicrobial discovery relies on targeting essential enzymes in pathogenic organisms, contributing to a paucity of new antibiotics to address resistant strains. Here, by targeting a non-essential enzyme, Borrelia burgdorferi...
4.
Turner S, Al-Ghabkari A, Carlson D, Chappellaz M, Sutherland C, Haystead T, et al.
Exp Physiol
. 2023 Apr;
108(7):986-997.
PMID: 37084168
New Findings: What is the central question of this study? DAPK3 contributes to the Ca -sensitization of vascular smooth muscle contraction: does this protein kinase participate in the myogenic response...
5.
Scarneo S, Smith A, Favret J, OConnell R, Pickeral J, Yang K, et al.
Sci Rep
. 2022 Oct;
12(1):18091.
PMID: 36302951
Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified...
6.
Kaneko K, Acharya C, Nagata H, Yang X, Hartman Z, Hobeika A, et al.
J Immunother Cancer
. 2022 Sep;
10(9).
PMID: 36171008
Background: We previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel tumor-specific photosensitizer (HS201), which binds heat shock protein 90 (HS201-PDT). However,...
7.
Karthigeyan K, Zhang L, Loiselle D, Haystead T, Bhat M, Yount J, et al.
J Biol Chem
. 2021 Oct;
297(5):101272.
PMID: 34606827
Mammalian cells acquire fatty acids (FAs) from dietary sources or via de novo palmitate production by fatty acid synthase (FASN). Although most cells express FASN at low levels, it is...
8.
Totzke J, Scarneo S, Yang K, Haystead T
Open Biol
. 2020 Sep;
10(9):200099.
PMID: 32873150
Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory diseases including rheumatoid arthritis (RA), irritable bowel disease and lupus. Maladaptive TNF signalling can lead to hyper active...
9.
Scarneo S, Yang K, Roques J, Dai A, Eibschutz L, Hughes P, et al.
Oncotarget
. 2020 Jun;
11(21):1961-1970.
PMID: 32523651
Transforming growth factor beta-activated kinase 1 (TAK1) has been implicated for its role in inflammatory signaling and as an important mediator of cellular apoptosis and necroptosis in various cell types....
10.
Scarneo S, Hughes P, Yang K, Carlson D, Gurbani D, Westover K, et al.
J Biol Chem
. 2020 Jan;
295(6):1565-1574.
PMID: 31914413
Interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-4, as well as transforming growth factor β-activated kinase 1 (TAK1), are protein kinases essential for transducing inflammatory signals from interleukin receptors. IRAK family proteins...