Timothy A Crombie
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Explore the profile of Timothy A Crombie including associated specialties, affiliations and a list of published articles.
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16
Citations
178
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Recent Articles
1.
Crombie T, Rajaei M, Saxena A, Johnson L, Saber S, Tanny R, et al.
Genetics
. 2024 Aug;
228(2).
PMID: 39139098
The distribution of fitness effects of new mutations plays a central role in evolutionary biology. Estimates of the distribution of fitness effect from experimental mutation accumulation lines are compromised by...
2.
Crombie T, McKeown R, Moya N, Evans K, Widmayer S, LaGrassa V, et al.
Nucleic Acids Res
. 2023 Oct;
52(D1):D850-D858.
PMID: 37855690
Studies of model organisms have provided important insights into how natural genetic differences shape trait variation. These discoveries are driven by the growing availability of genomes and the expansive experimental...
3.
Shaver A, Wit J, Dilks C, Crombie T, Li H, Aroian R, et al.
PLoS Pathog
. 2023 Apr;
19(4):e1011285.
PMID: 37011090
Treatment of parasitic nematode infections in humans and livestock relies on a limited arsenal of anthelmintic drugs that have historically reduced parasite burdens. However, anthelmintic resistance (AR) is increasing, and...
4.
Widmayer S, Crombie T, Nyaanga J, Evans K, Andersen E
Toxicology
. 2022 Aug;
479:153292.
PMID: 35995124
The genetic variability of toxicant responses among indisviduals in humans and mammalian models requires practically untenable sample sizes to create comprehensive chemical hazard risk evaluations. To address this need, tractable...
5.
Fox B, Ponomarova O, Lee Y, Zhang G, Giese G, Walker M, et al.
Nature
. 2022 Jul;
607(7919):571-577.
PMID: 35794472
Individuals can exhibit differences in metabolism that are caused by the interplay of genetic background, nutritional input, microbiota and other environmental factors. It is difficult to connect differences in metabolism...
6.
Crombie T, Chikuturudzi C, Cook D, Andersen E
MicroPubl Biol
. 2022 Jun;
2022.
PMID: 35647500
Chemotaxis assays are used extensively to study behavioral responses of nematodes to environmental cues. These assays result in a chemotaxis index (CI) that denotes the behavioral response of a population...
7.
Crombie T, Tanny R, Buchanan C, Roberto N, Andersen E
J Vis Exp
. 2022 Mar;
(181).
PMID: 35311808
Caenorhabditis elegans is one of the major model organisms in biology, but only recently have researchers focused on its natural ecology. The relative sparsity of information about C. elegans in...
8.
Crombie T, Battlay P, Tanny R, Evans K, Buchanan C, Cook D, et al.
Mol Ecol
. 2022 Feb;
31(8):2327-2347.
PMID: 35167162
The nematode Caenorhabditis elegans is among the most widely studied organisms, but relatively little is known about its natural ecology. Genetic diversity is low across much of the globe but...
9.
Di Bernardo M, Crombie T, Cook D, Andersen E
PLoS One
. 2021 Oct;
16(10):e0254293.
PMID: 34613959
Large-scale ecological sampling can be difficult and costly, especially for organisms that are too small to be easily identified in a natural environment by eye. Typically, these microscopic floral and...
10.
Rajaei M, Saxena A, Johnson L, Snyder M, Crombie T, Tanny R, et al.
Genome Res
. 2021 Aug;
31(9):1602-1613.
PMID: 34404692
Important clues about natural selection can be gleaned from discrepancies between the properties of segregating genetic variants and of mutations accumulated experimentally under minimal selection, provided the mutational process is...