Tim E Cawston
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Explore the profile of Tim E Cawston including associated specialties, affiliations and a list of published articles.
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26
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Recent Articles
1.
Hui W, Young D, Rowan A, Xu X, Cawston T, Proctor C
Ann Rheum Dis
. 2014 Dec;
75(2):449-58.
PMID: 25475114
Objective: To use a computational approach to investigate the cellular and extracellular matrix changes that occur with age in the knee joints of mice. Methods: Knee joints from an inbred...
2.
Hui W, Litherland G, Elias M, Kitson G, Cawston T, Rowan A, et al.
Ann Rheum Dis
. 2011 Nov;
71(3):455-62.
PMID: 22072016
Objectives: To investigate the effect of leptin on cartilage destruction. Methods: Collagen release was assessed in bovine cartilage explant cultures, while collagenolytic and gelatinolytic activities in culture supernatants were determined...
3.
Barter M, Hui W, Lakey R, Catterall J, Cawston T, Young D
Ann Rheum Dis
. 2010 Aug;
69(12):2189-98.
PMID: 20693272
Objective: To investigate if statins prevent cartilage degradation and the production of collagenases and gelatinases in bovine nasal and human articular cartilage after proinflammatory cytokine stimulation. Methods: In a cartilage...
4.
Hui W, Litherland G, Jefferson M, Barter M, Elias M, Cawston T, et al.
Rheumatology (Oxford)
. 2010 Jul;
49(11):2043-53.
PMID: 20634235
Objectives: To determine the effects and mechanism of action of lithium chloride (LiCl) on cartilage destruction induced by the pro-inflammatory cytokines IL-1, IL-1 + oncostatin M and TNF-α. Methods: The...
5.
Milner J, Patel A, Davidson R, Swingler T, Desilets A, Young D, et al.
Arthritis Rheum
. 2010 May;
62(7):1955-66.
PMID: 20506309
Objective: Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in...
6.
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes
Barter M, Pybus L, Litherland G, Rowan A, Clark I, Edwards D, et al.
Matrix Biol
. 2010 May;
29(7):602-12.
PMID: 20470885
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-β signalling pathway components such as Smad2,...
7.
Hui W, Cawston T
Methods Mol Biol
. 2010 Feb;
622:341-8.
PMID: 20135292
This 14-day model of cartilage breakdown involves stimulation of bovine nasal cartilage with a combination of interleukin-1 and oncostatin M. Media is harvested on days 7 and 14 and the...
8.
Cawston T, Lakey R, Rowan A
Methods Mol Biol
. 2010 Feb;
622:245-55.
PMID: 20135287
The assays described allow the activity of members of the matrix metalloproteinase (MMP) family that degrade collagen, gelatin and casein substrates to be measured. The protocols described include the preparation...
9.
Cawston T, Young D
Cell Tissue Res
. 2009 Nov;
339(1):221-35.
PMID: 19915869
The joint is a discrete unit that consists of cartilage, bone, tendon and ligaments. These tissues are all composed of an extracellular matrix made of collagens, proteoglycans and specialised glycoproteins...
10.
Lakey R, Cawston T
Rheumatology (Oxford)
. 2009 Aug;
48(10):1208-12.
PMID: 19690126
Objective: To investigate the effect of SSZ on the release of GAG and collagen fragments from bovine nasal cartilage and MMP and ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin...