David A Young
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Explore the profile of David A Young including associated specialties, affiliations and a list of published articles.
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109
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2812
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Recent Articles
1.
Niu L, Swingler T, Suelzu C, Ersek A, Orriss I, Barter M, et al.
JBMR Plus
. 2025 Feb;
9(3):ziaf007.
PMID: 39963339
A wide range of specific microRNAs have been shown to have either positive or negative effects on osteoblast differentiation and function, with consequent changes in postnatal bone mass. A number...
2.
McDonnell E, Orr S, Barter M, Rux D, Brumwell A, Wrobel N, et al.
Am J Hum Genet
. 2024 Nov;
111(12):2756-2772.
PMID: 39579763
Increasing evidence is emerging to link age-associated complex musculoskeletal diseases, including osteoarthritis (OA), to developmental factors. Multiple studies have shown a functional role for DNA methylation in the genetic mechanisms...
3.
Hayman D, Johnson de Sousa Brito F, Lin H, Prior A, Charlesworth G, Hao Y, et al.
Bone
. 2024 Oct;
190:117273.
PMID: 39383985
MicroRNAs (miRNAs) modulate the expression of other RNA molecules. One miRNA can target many transcripts, allowing each miRNA to play key roles in many biological pathways. Defects in bone homeostasis...
4.
Gilbert S, Soul J, Hao Y, Lin H, Pirog K, Coxhead J, et al.
Dis Model Mech
. 2024 Sep;
17(10).
PMID: 39314058
Animal models of post-traumatic osteoarthritis (PTOA) recapitulate the pathological changes observed in human PTOA. Here, skeletally mature C57Bl6 mice were subjected to either rapid-onset non-surgical mechanical rupture of the anterior...
5.
Barter M, Turner D, Rice S, Hines M, Lin H, Falconer A, et al.
Matrix Biol
. 2024 Aug;
133:33-42.
PMID: 39097037
Serine proteinase inhibitors (serpins) are a family of structurally similar proteins which regulate many diverse biological processes from blood coagulation to extracellular matrix (ECM) remodelling. Chondrogenesis involves the condensation and...
6.
Lin D, Xu J, Weinrauch P, Young D, De Smet K, Manktelow A, et al.
J Arthroplasty
. 2024 May;
39(11):2800-2806.
PMID: 38782243
Background: Hip resurfacing arthroplasty (HRA) is a bone-conserving alternative to total hip arthroplasty. We present the 2-year clinical and radiographic follow-up of a novel ceramic-on-ceramic HRA in an international multicenter...
7.
McDonnell E, Orr S, Barter M, Rux D, Brumwell A, Wrobel N, et al.
medRxiv
. 2024 May;
PMID: 38766055
The epigenome, including the methylation of cytosine bases at CG dinucleotides, is intrinsically linked to transcriptional regulation. The tight regulation of gene expression during skeletal development is essential, with ~1/500...
8.
Dhawan R, Young D, Van Eemeren A, Shimmin A
Bone Joint J
. 2023 Aug;
105-B(9):946-952.
PMID: 37652450
Aims: The Birmingham Hip Resurfacing (BHR) arthroplasty has been used as a surgical treatment of coxarthrosis since 1997. We present 20-year results of 234 consecutive BHRs performed in our unit....
9.
Gomez R, Barter M, Alonso-Perez A, Skelton A, Proctor C, Herrero-Beaumont G, et al.
Biol Res
. 2023 Mar;
56(1):9.
PMID: 36890579
Background: Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-methylation changes during osteoblastogenesis...
10.
Barter M, Butcher A, Wang H, Tsompani D, Galler M, Rumsby E, et al.
Sci Rep
. 2022 Apr;
12(1):6640.
PMID: 35459919
Elevated pro-inflammatory signalling coupled with catabolic metalloproteinase expression is a common feature of arthritis, leading to cartilage damage, deterioration of the joint architecture and the associated pain and immobility. Countering...