Tilman Borggrefe
Overview
Explore the profile of Tilman Borggrefe including associated specialties, affiliations and a list of published articles.
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58
Citations
1815
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Recent Articles
1.
Huynh D, Hoffmeister P, Friedrich T, Zhang K, Bartkuhn M, Ferrante F, et al.
Nat Commun
. 2025 Feb;
16(1):1259.
PMID: 39893191
Transcription factors (TFs) such as RBPJ in Notch signaling bind to specific DNA sequences to regulate transcription. How TF-DNA binding kinetics and cofactor interactions modulate gene regulation is mostly unknown....
2.
Giaimo B, Ferrante F, Borggrefe T
Cell Mol Life Sci
. 2024 Dec;
82(1):5.
PMID: 39680066
Post-translational modifications (PTMs) are implicated in many biological processes including receptor activation, signal transduction, transcriptional regulation and protein turnover. Lysine's side chain is particularly notable, as it can undergo methylation,...
3.
Giaimo B, Friedrich T, Ferrante F, Bartkuhn M, Borggrefe T
Nucleic Acids Res
. 2024 Apr;
52(9):5179-5194.
PMID: 38647081
Transcription factor RBPJ is the central component in Notch signal transduction and directly forms a coactivator complex together with the Notch intracellular domain (NICD). While RBPJ protein levels remain constant...
4.
Taylor J, Uhl L, Moll I, Hasan S, Wiedmann L, Morgenstern J, et al.
Nat Cancer
. 2023 Sep;
4(11):1544-1560.
PMID: 37749321
Cachexia is a major cause of morbidity and mortality in individuals with cancer and is characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white adipose...
5.
Herchenrother A, Gossen S, Friedrich T, Reim A, Daus N, Diegmuller F, et al.
Nat Commun
. 2023 Jan;
14(1):472.
PMID: 36709316
Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A as a direct histone variant H2A.Z interactor involved in mitosis and craniofacial development. Here, we identify...
6.
Hall D, Giaimo B, Park S, Hemmer W, Friedrich T, Ferrante F, et al.
Nucleic Acids Res
. 2022 Dec;
50(22):13083-13099.
PMID: 36477367
The Notch pathway transmits signals between neighboring cells to elicit downstream transcriptional programs. Notch is a major regulator of cell fate specification, proliferation, and apoptosis, such that aberrant signaling leads...
7.
Alsina-Sanchis E, Mulfarth R, Moll I, Bohn S, Wiedmann L, Jordana-Urriza L, et al.
Cancer Res
. 2022 Oct;
82(23):4414-4428.
PMID: 36200806
Significance: Endothelial Notch signaling favors immunosuppression by increasing CXCL2 secretion to stimulate CD44 expression in macrophages, facilitating their education by tumor cells.
8.
Merle N, Elmshauser S, Strassheimer F, Wanzel M, Konig A, Funk J, et al.
Mol Cancer
. 2022 Oct;
21(1):191.
PMID: 36192757
Background: In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease...
9.
Giaimo B, Borggrefe T
Signal Transduct Target Ther
. 2022 Aug;
7(1):281.
PMID: 35961952
No abstract available.
10.
Gagliani E, Gutzwiller L, Kuang Y, Odaka Y, Hoffmeister P, Hauff S, et al.
PLoS Genet
. 2022 Aug;
18(8):e1010335.
PMID: 35951645
Notch signaling is a conserved pathway that converts extracellular receptor-ligand interactions into changes in gene expression via a single transcription factor (CBF1/RBPJ in mammals; Su(H) in Drosophila). In humans, RBPJ...