Tian V Tian
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Explore the profile of Tian V Tian including associated specialties, affiliations and a list of published articles.
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24
Citations
363
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Recent Articles
11.
Serra-Camprubi Q, Verdaguer H, Oliveros W, Lupion-Garcia N, Llop-Guevara A, Molina C, et al.
Clin Cancer Res
. 2022 Nov;
29(2):432-445.
PMID: 36374558
Purpose: Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2,...
12.
Boix O, Martinez M, Vidal S, Gimenez-Alejandre M, Palenzuela L, Lorenzo-Sanz L, et al.
Nat Commun
. 2022 Nov;
13(1):6840.
PMID: 36369429
The human transcriptome contains thousands of small open reading frames (sORFs) that encode microproteins whose functions remain largely unexplored. Here, we show that TINCR lncRNA encodes pTINCR, an evolutionary conserved...
13.
Plana-Carmona M, Stik G, Bulteau R, Segura-Morales C, Alcazar N, Wyatt C, et al.
Stem Cell Reports
. 2022 Aug;
17(9):1991-2004.
PMID: 35961310
IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during...
14.
Tian T, Sardina J
Methods Mol Biol
. 2021 May;
2272:239-250.
PMID: 34009618
Ten-eleven Translocation (TET) enzymes are methylcytosine dioxygenases that are involved in multiple cellular processes, including cellular differentiation and forced cell fate conversions. However, deciphering the molecular mechanisms underlying epigenetic control...
15.
Choi J, Lysakovskaia K, Stik G, Demel C, Soding J, Tian T, et al.
Elife
. 2021 Mar;
10.
PMID: 33770473
Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear how enhancers cooperate during these processes. Here we investigate enhancer cooperation during transdifferentiation of human leukemia B-cells...
16.
Stik G, Vidal E, Barrero M, Cuartero S, Vila-Casadesus M, Mendieta-Esteban J, et al.
Nat Genet
. 2020 Jun;
52(7):655-661.
PMID: 32514124
Three-dimensional organization of the genome is important for transcriptional regulation. In mammals, CTCF and the cohesin complex create submegabase structures with elevated internal chromatin contact frequencies, called topologically associating domains...
17.
Tian T, Vidal E, Graf T, Stik G
J Vis Exp
. 2020 May;
(158).
PMID: 32420995
During mammalian development, cell fates are determined through the establishment of regulatory networks that define the specificity, timing, and spatial patterns of gene expression. Embryoid bodies (EBs) derived from pluripotent...
18.
Tian T, Di Stefano B, Stik G, Vila-Casadesus M, Sardina J, Vidal E, et al.
Nat Cell Biol
. 2019 Jun;
21(7):824-834.
PMID: 31235934
How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here, we show that the chromatin-related factor Whsc1 (also known as Nsd2 and...
19.
Sardina J, Collombet S, Tian T, Gomez A, Di Stefano B, Berenguer C, et al.
Cell Stem Cell
. 2018 Dec;
23(6):905-906.
PMID: 30526885
No abstract available.
20.
Sardina J, Collombet S, Tian T, Gomez A, Di Stefano B, Berenguer C, et al.
Cell Stem Cell
. 2018 Sep;
23(5):727-741.e9.
PMID: 30220521
Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs). We observed successive waves of hydroxymethylation at enhancers,...