Bruno Di Stefano
Overview
Explore the profile of Bruno Di Stefano including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
1800
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Recent Articles
1.
Kodali S, Sands C, Guo L, Huang Y, Di Stefano B
Nat Rev Immunol
. 2025 Jan;
PMID: 39875604
Fate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation of these changes is associated with the formation of diverse, membrane-less...
2.
Levin-Ferreyra F, Kodali S, Cui Y, Pashos A, Pessina P, Brumbaugh J, et al.
EMBO Rep
. 2024 Dec;
26(2):329-352.
PMID: 39668246
Human pluripotent stem cells (hPSCs) exist in multiple, transcriptionally distinct states and serve as powerful models for studying human development. Despite their significance, the molecular determinants and pathways governing these...
3.
Guo L, Hong T, Lee Y, Hu X, Pan G, Zhao R, et al.
Nat Cell Biol
. 2024 Sep;
26(12):2154-2167.
PMID: 39251719
The ten-eleven translocation (TET) family of dioxygenases maintain stable local DNA demethylation during cell division and lineage specification. As the major catalytic product of TET enzymes, 5-hydroxymethylcytosine is selectively enriched...
4.
Kodali S, Proietti L, Valcarcel G, Lopez-Rubio A, Pessina P, Eder T, et al.
Nat Cell Biol
. 2024 Aug;
26(10):1745-1758.
PMID: 39169219
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through...
5.
Maneix L, Iakova P, Lee C, Moree S, Lu X, Datar G, et al.
Nat Cell Biol
. 2024 Mar;
26(4):593-603.
PMID: 38553595
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin A) as a dominant chaperone in haematopoietic stem and progenitor cells....
6.
Hoetker M, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong L, et al.
Nat Cell Biol
. 2023 Jul;
25(8):1121-1134.
PMID: 37460697
The epigenetic mechanisms that maintain differentiated cell states remain incompletely understood. Here we employed histone mutants to uncover a crucial role for H3K36 methylation in the maintenance of cell identities...
7.
Park E, Kodali S, Di Stefano B
Cell Stem Cell
. 2023 Apr;
30(4):335-337.
PMID: 37028396
Small molecule-induced cell fate transitions are characterized by low efficiency and slow kinetics. An optimized chemical reprogramming approach now facilitates the robust and rapid conversion of somatic cells to pluripotent...
8.
Pessina P, Di Stefano B
Cell Reprogram
. 2023 Jan;
25(1):9-10.
PMID: 36594927
Short-term expression of Yamanaka factors early in life promotes epigenetic reprogramming and an increased healthy lifespan in a mouse model of accelerated aging.
9.
Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, et al.
Science
. 2022 Dec;
378(6623):983-989.
PMID: 36454826
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage...
10.