Tiago M Bandeiras
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Explore the profile of Tiago M Bandeiras including associated specialties, affiliations and a list of published articles.
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52
Citations
813
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Recent Articles
1.
Heinrich T, Schwarz D, Petersson C, Gunera J, Garg S, Schneider R, et al.
J Med Chem
. 2024 Dec;
PMID: 39704449
Taking the structural information into account, we were able to tune the TEAD selectivity for a specific chemotype. However, different TEAD selectivity profiles did not affect the compound potency or...
2.
Bailey H, Eisert J, Kazi R, Gerhartz J, Pienkowska D, Dressel I, et al.
Cell Chem Biol
. 2024 Nov;
32(2):363-376.e10.
PMID: 39610248
The majority of clinical degraders utilize an immunomodulatory imide drug (IMiD)-based derivative that directs their target to the E3 ligase receptor cereblon (CRBN); however, identification of IMiD molecular glue substrates...
3.
Abeza C, Busse P, Paiva A, Chagot M, Schneider J, Robert M, et al.
J Mol Biol
. 2024 Nov;
436(23):168840.
PMID: 39490680
The R2TP chaperone is composed of the RUVBL1/RUVBL2 AAA+ ATPases and two adapter proteins, RPAP3 and PIH1D1. Together with HSP90, it functions in the assembly of macromolecular complexes that are...
4.
Fernandez-Quintero M, Guarnera E, Musil D, Pekar L, Sellmann C, Freire F, et al.
Protein Sci
. 2024 Oct;
33(11):e5176.
PMID: 39422475
The humanization of camelid-derived variable domain heavy chain antibodies (VHHs) poses challenges including immunogenicity, stability, and potential reduction of affinity. Critical to this process are complementarity-determining regions (CDRs), Vernier and...
5.
Pires C, Marques I, Saramago A, Moura M, Pojo M, Cabrera R, et al.
Int J Cancer
. 2024 Sep;
156(1):130-144.
PMID: 39251783
The genetic basis of nonsyndromic familial nonmedullary thyroid carcinoma (FNMTC) is still poorly understood, as the susceptibility genes identified so far only account for a small percentage of the genetic...
6.
Gizardin-Fredon H, Santo P, Chagot M, Charpentier B, Bandeiras T, Manival X, et al.
Nat Commun
. 2024 Apr;
15(1):3516.
PMID: 38664367
Chemical cross-linking reactions (XL) are an important strategy for studying protein-protein interactions (PPIs), including low abundant sub-complexes, in structural biology. However, choosing XL reagents and conditions is laborious and mostly...
7.
Ferreira I, Torrejon E, Abecasis B, Alexandre B, Gomes R, Verslype C, et al.
SLAS Discov
. 2024 Mar;
29(3):100154.
PMID: 38521503
Sorafenib is a multikinase inhibitor indicated for first-line treatment of unresectable hepatocellular carcinoma. Despite its widespread use in the clinic, the existing knowledge of sorafenib mode-of-action remains incomplete. To build...
8.
Pires C, Marques I, Valerio M, Saramago A, Santo P, Santos S, et al.
J Biol Chem
. 2024 Feb;
300(3):105767.
PMID: 38367672
Approximately 5 to 15% of nonmedullary thyroid cancers (NMTC) present in a familial form (familial nonmedullary thyroid cancers [FNMTC]). The genetic basis of FNMTC remains largely unknown, representing a limitation...
9.
Paiva A, Lemos A, Busse P, Martins M, Silva D, Freitas M, et al.
Biosensors (Basel)
. 2023 Oct;
13(10).
PMID: 37887106
Modern drug discovery relies on combinatorial screening campaigns to find drug molecules targeting specific disease-associated proteins. The success of such campaigns often relies on functional and structural information of the...
10.
Gradler U, Schwarz D, Wegener A, Eichhorn T, Bandeiras T, Freitas M, et al.
J Biol Chem
. 2023 Oct;
299(11):105328.
PMID: 37806493
The receptor tyrosine kinase MET is activated by hepatocyte growth factor binding, followed by phosphorylation of the intracellular kinase domain (KD) mainly within the activation loop (A-loop) on Y1234 and...