Micael C Freitas
Overview
Explore the profile of Micael C Freitas including associated specialties, affiliations and a list of published articles.
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6
Citations
76
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0
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Recent Articles
1.
Fernandez-Quintero M, Guarnera E, Musil D, Pekar L, Sellmann C, Freire F, et al.
Protein Sci
. 2024 Oct;
33(11):e5176.
PMID: 39422475
The humanization of camelid-derived variable domain heavy chain antibodies (VHHs) poses challenges including immunogenicity, stability, and potential reduction of affinity. Critical to this process are complementarity-determining regions (CDRs), Vernier and...
2.
Paiva A, Lemos A, Busse P, Martins M, Silva D, Freitas M, et al.
Biosensors (Basel)
. 2023 Oct;
13(10).
PMID: 37887106
Modern drug discovery relies on combinatorial screening campaigns to find drug molecules targeting specific disease-associated proteins. The success of such campaigns often relies on functional and structural information of the...
3.
Gradler U, Schwarz D, Wegener A, Eichhorn T, Bandeiras T, Freitas M, et al.
J Biol Chem
. 2023 Oct;
299(11):105328.
PMID: 37806493
The receptor tyrosine kinase MET is activated by hepatocyte growth factor binding, followed by phosphorylation of the intracellular kinase domain (KD) mainly within the activation loop (A-loop) on Y1234 and...
4.
Castro R, Nobre L, Eleuterio R, Thomaz M, Pires A, Monteiro S, et al.
Biotechnol Bioeng
. 2021 Feb;
118(6):2202-2219.
PMID: 33624859
Serological assays are valuable tools to study SARS-CoV-2 spread and, importantly, to identify individuals that were already infected and would be potentially immune to a virus reinfection. SARS-CoV-2 Spike protein...
5.
Bandeiras T, Freitas M, Petrasch D, Kletzin A, Frazao C
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2013 May;
69(Pt 5):555-8.
PMID: 23695576
Rieske proteins and Rieske ferredoxins are ubiquitous electron-transfer metalloproteins that are characterized by a [2Fe-2S] cluster coordinated by pairs of cysteine and histidine residues. The thermoacidophilic archaeon Acidianus ambivalens contains...
6.
Carvalho-Santos Z, Machado P, Alvarez-Martins I, Gouveia S, Jana S, Duarte P, et al.
Dev Cell
. 2012 Aug;
23(2):412-24.
PMID: 22898782
Cilia and flagella are involved in a variety of processes and human diseases, including ciliopathies and sterility. Their motility is often controlled by a central microtubule (MT) pair localized within...