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Thomas Xue

Explore the profile of Thomas Xue including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 9
Citations 16
Followers 0
Related Specialties
Orthopedics
Biomedical Engineering
General Medicine
Top 10 Co-Authors
Youliang Ren
Chao Xie
Joshua Rainbolt
Jason Weeks
Edward M Schwarz
Ye Shu
Yuting Liu
Jeffrey Neighbors
Shu-Chi A Yeh
Philip Cherian
Published In
J Orthop Res
Front Cell Infect Microbiol
Bone Res
Bioact Mater
bioRxiv
Affiliations
Soon will be listed here.
Recent Articles
1.
Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation
Zhou H, Ren Y, Zou K, Jin Y, Liu H, Jiang H, et al.
Adv Healthc Mater . 2024 Nov; 14(3):e2403261. PMID: 39604325
Implant-associated Staphylococcus aureus (S. aureus) osteomyelitis (IASO) leads to high orthopedic implant failure rates due to the formation of Staphylococcal abscess community within the bone marrow and bacterial colonization in...
2.
Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and FeO magnetic nanoparticle scaffold on implant-associated bone infection
Jin Y, Liu H, Chu L, Yang J, Li X, Zhou H, et al.
Bioact Mater . 2024 Jul; 40:148-167. PMID: 38962659
Implant-associated () osteomyelitis is a severe challenge in orthopedics. While antibiotic-loaded bone cement is a standardized therapeutic approach for osteomyelitis, it falls short in eradicating Staphylococcus abscess communities (SACs) and...
3.
A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model
Lekkala S, Ren Y, Weeks J, Lee K, Tay A, Liu B, et al.
PLoS One . 2024 Jun; 19(6):e0296140. PMID: 38900759
Implant-associated osteomyelitis remains a major orthopaedic problem. As neutrophil swarming to the surgical site is a critical host response to prevent infection, visualization and quantification of this dynamic behavior at...
4.
A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and contaminated bone implants in a mouse femur model
Lekkala S, Ren Y, Weeks J, Lee K, Tay A, Liu B, et al.
bioRxiv . 2023 Dec; PMID: 38105961
Implant-associated osteomyelitis remains a major orthopaedic problem. As neutrophil swarming to the surgical site is a critical host response to prevent infection, visualization and quantification of this dynamic behavior at...
5.
Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis
Ren Y, Weeks J, Xue T, Rainbolt J, Bentley K, Shu Y, et al.
Bone Res . 2023 Oct; 11(1):51. PMID: 37848449
Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve "target-and-release" drug delivery proximal to...
6.
Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model
Xie C, Ren Y, Weeks J, Rainbolt J, Kenney H, Xue T, et al.
J Orthop Res . 2023 Oct; 42(3):531-538. PMID: 37812184
Critical knowledge gaps of orthopedic infections pertain to bacterial colonization. The established dogma termed the Race for the Surface posits that contaminating bacteria compete with host cells for the implant...
7.
Evidence of Bisphosphonate-Conjugated Sitafloxacin Eradication of Established Methicillin-Resistant S. aureus Infection with Osseointegration in Murine Models of Implant-Associated Osteomyelitis
Xie C, Ren Y, Weeks J, Xue T, Rainbolt J, Bentley K, et al.
Res Sq . 2023 May; PMID: 37214929
Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve "target-and-release" drug delivery proximal to...
8.
Reduced angiogenesis and delayed endochondral ossification in CD163 mice highlights a role of M2 macrophages during bone fracture repair
Ren Y, Zhang S, Weeks J, Moreno J, He B, Xue T, et al.
J Orthop Res . 2023 Mar; 41(11):2384-2393. PMID: 36970754
While recent studies showed that macrophages are critical for bone fracture healing, and lack of M2 macrophages have been implicated in models of delayed union, functional roles for specific M2...
9.
Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi
Ren Y, Xue T, Rainbolt J, Bentley K, Galloway C, Liu Y, et al.
Front Cell Infect Microbiol . 2022 Jul; 12:910970. PMID: 35811672
infection of bone is difficult to eradicate due to its ability to colonize the osteocyte-lacuno-canalicular network (OLCN), rendering it resistant to standard-of-care (SOC) antibiotics. To overcome this, we proposed two...