Thomas W M Crozier
Overview
Explore the profile of Thomas W M Crozier including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
541
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0
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Recent Articles
1.
Shilts J, Crozier T, Teixeira-Silva A, Gabaev I, Pereyra Gerber P, Greenwood E, et al.
PLoS Biol
. 2023 Feb;
21(2):e3001959.
PMID: 36735681
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to Coronavirus Disease 2019 (COVID-19). The spike protein...
2.
Crozier T, Greenwood E, Williamson J, Guo W, Porter L, Gabaev I, et al.
Wellcome Open Res
. 2022 Dec;
7:224.
PMID: 36483314
Quantitative proteomics is able to provide a comprehensive, unbiased description of changes to cells caused by viral infection, but interpretation may be complicated by differential changes in infected and uninfected...
3.
Brevini T, Maes M, Webb G, John B, Fuchs C, Buescher G, et al.
Nature
. 2022 Dec;
615(7950):134-142.
PMID: 36470304
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for COVID-19 that complements vaccination. However, the mechanisms that control...
4.
Perera M, Greenwood E, Crozier T, Elder E, Schmitt J, Crump C, et al.
J Infect Dis
. 2022 Nov;
227(4):543-553.
PMID: 36408607
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate...
5.
Fielding C, Sabberwal P, Williamson J, Greenwood E, Crozier T, Zelek W, et al.
Elife
. 2022 May;
11.
PMID: 35587364
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion....
6.
Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull M, et al.
Science
. 2021 Sep;
374(6567):eabj3624.
PMID: 34581622
Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and...
7.
Shilts J, Crozier T, Greenwood E, Lehner P, Wright G
Sci Rep
. 2021 Jan;
11(1):413.
PMID: 33432067
The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was...
8.
Gabaev I, Williamson J, Crozier T, Schulz T, Lehner P
Cell Rep
. 2020 Oct;
33(2):108249.
PMID: 33053346
Kaposi's sarcoma herpesvirus (KSHV) is an oncogenic human virus and the leading cause of mortality in HIV infection. KSHV reactivation from latent- to lytic-stage infection initiates a cascade of viral...
9.
Tinti M, Guther M, Crozier T, Lamond A, Ferguson M
Wellcome Open Res
. 2019 Nov;
4:152.
PMID: 31681858
: Cellular proteins vary significantly in both abundance and turnover rates. These parameters depend upon their rates of synthesis and degradation and it is useful to have access to data...
10.
Mattos E, Canuto G, Manchola N, Magalhaes R, Crozier T, Lamont D, et al.
PLoS Negl Trop Dis
. 2019 Feb;
13(2):e0007103.
PMID: 30726203
Trypanosoma cruzi, the etiological agent of Chagas' disease, affects 8 million people predominantly living in socioeconomic underdeveloped areas. T. cruzi trypomastigotes (Ty), the classical infective stage, interact with the extracellular...