Thomas S OLeary
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Explore the profile of Thomas S OLeary including associated specialties, affiliations and a list of published articles.
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11
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224
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Recent Articles
1.
OLeary T, Mikucki E, Tangwancharoen S, Boyd J, Frietze S, Helms Cahan S, et al.
bioRxiv
. 2025 Jan;
PMID: 39829925
Embryogenesis is remarkably robust to temperature variability, yet there is limited understanding of the homeostatic mechanisms that offset thermal effects during early development. Here, we measured the thermal acclimation response...
2.
Mikucki E, OLeary T, Lockwood B
Proc Biol Sci
. 2024 Aug;
291(2029):20240973.
PMID: 39163981
In organisms with complex life cycles, life stages that are most susceptible to environmental stress may determine species persistence in the face of climate change. Early embryos of are particularly...
3.
Barefield D, Tonino P, Woulfe K, Rahmanseresht S, OLeary T, Burnham H, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(51):e2314920120.
PMID: 38091294
Mutations in atrial-enriched genes can cause a primary atrial myopathy that can contribute to overall cardiovascular dysfunction. encodes myosin-binding protein H-like (MyBP-HL), an atrial sarcomere protein that shares domain homology...
4.
Wood N, Kelly C, OLeary T, Martin J, Previs M
Mol Cell Proteomics
. 2022 Aug;
21(10):100274.
PMID: 35921914
Myosin and myosin-binding protein C are exquisitely organized into giant filamentous macromolecular complexes within cardiac muscle sarcomeres, yet these proteins must be continually replaced to maintain contractile fidelity. The overall...
5.
Previs M, OLeary T, Morley M, Palmer B, LeWinter M, Yob J, et al.
Circ Heart Fail
. 2022 May;
15(6):e009521.
PMID: 35543134
Background: Defects in energetics are thought to be central to the pathophysiology of hypertrophic cardiomyopathy (HCM); yet, the determinants of ATP availability are not known. The purpose of this study...
6.
Tsan Y, DePalma S, Zhao Y, Capilnasiu A, Wu Y, Elder B, et al.
Nat Commun
. 2021 Oct;
12(1):6167.
PMID: 34697315
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) allow investigations in a human cardiac model system, but disorganized mechanics and immaturity of hPSC-CMs on standard two-dimensional surfaces have been hurdles. Here, we...
7.
Rahmanseresht S, Lee K, OLeary T, McNamara J, Sadayappan S, Robbins J, et al.
J Gen Physiol
. 2021 Feb;
153(3).
PMID: 33528507
Myosin and actin filaments are highly organized within muscle sarcomeres. Myosin-binding protein C (MyBP-C) is a flexible, rod-like protein located within the C-zone of the sarcomere. The C-terminal domain of...
8.
Daneshparvar N, Taylor D, OLeary T, Rahmani H, Abbasiyeganeh F, Previs M, et al.
Life Sci Alliance
. 2020 Jul;
3(8).
PMID: 32718994
Striated muscle thick filaments are composed of myosin II and several non-myosin proteins. Myosin II's long α-helical coiled-coil tail forms the dense protein backbone of filaments, whereas its N-terminal globular...
9.
Lecheta M, Awde D, OLeary T, Unfried L, Jacobs N, Whitlock M, et al.
Front Genet
. 2020 Jul;
11:658.
PMID: 32655626
Thermal tolerance of an organism depends on both the ability to dynamically adjust to a thermal stress and preparatory developmental processes that enhance thermal resistance. However, the extent to which...
10.
Helms A, Tang V, OLeary T, Friedline S, Wauchope M, Arora A, et al.
JCI Insight
. 2019 Dec;
5(2).
PMID: 31877118
Mutations in cardiac myosin binding protein C (MyBP-C, encoded by MYBPC3) are the most common cause of hypertrophic cardiomyopathy (HCM). Most MYBPC3 mutations result in premature termination codons (PTCs) that...