Thomas S Kilduff
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Explore the profile of Thomas S Kilduff including associated specialties, affiliations and a list of published articles.
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83
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Recent Articles
21.
Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, et al.
Science
. 2019 Oct;
365(6459):1308-1313.
PMID: 31604241
The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone-producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in...
22.
Goonawardena A, Morairty S, Orellana G, Willoughby A, Wallace T, Kilduff T
Neurobiol Sleep Circadian Rhythms
. 2019 Jun;
6:9-23.
PMID: 31236518
Most preclinical sleep studies are conducted in nocturnal rodents that have fragmented sleep in comparison to humans who are primarily diurnal, typically with a consolidated sleep period. Consequently, we sought...
23.
Goonawardena A, Morairty S, Dell R, Orellana G, Hoener M, Wallace T, et al.
Neuropsychopharmacology
. 2019 Apr;
44(8):1485-1493.
PMID: 30954024
Trace amine-associated receptor 1 (TAAR1) is a G-protein coupled receptor with affinity for the trace amines. TAAR1 agonists have pro-cognitive, antidepressant-, and antipsychotic-like properties in both rodents and non-human primates...
24.
Szabo S, Thorpy M, Mayer G, Peever J, Kilduff T
Sleep Med Rev
. 2018 Dec;
43:23-36.
PMID: 30503715
Excessive daytime sleepiness (EDS) and cataplexy are common symptoms of narcolepsy, a sleep disorder associated with the loss of hypocretin/orexin (Hcrt) neurons. Although only a few drugs have received regulatory...
25.
Heiss J, Yamanaka A, Kilduff T
eNeuro
. 2018 Sep;
5(4).
PMID: 30225361
Until recently, hypocretin (Hcrt) neurons were the only known wake-promoting neuronal population in the lateral hypothalamus (LH), but subpopulations of inhibitory neurons in this area and glutamatergic neurons in the...
26.
Williams R, Black S, Thomas A, Piquet J, Cauli B, Kilduff T
Cereb Cortex
. 2018 Feb;
29(3):1090-1108.
PMID: 29462275
We have proposed that cortical nNOS/NK1R interneurons have a role in sleep homeostasis. The hypocretins (orexins) are wake-promoting neuropeptides and hypocretin/orexin (Hcrt) neurons project to the cortex. Hcrt peptides affect...
27.
Schwartz M, Palmerston J, Lee D, Hoener M, Kilduff T
Front Pharmacol
. 2018 Feb;
9:35.
PMID: 29456505
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic,...
28.
Thomas A, Schwartz M, Saxe M, Kilduff T
Sleep
. 2017 Sep;
40(10).
PMID: 28958035
Study Objectives: Neuroligin-3 (NLGN3) is one of the many genes associated with autism spectrum disorder (ASD). Sleep dysfunction is highly prevalent in ASD, but has not been rigorously examined in...
29.
30.
Gerashchenko D, Pasumarthi R, Kilduff T
Sleep
. 2017 Jun;
40(7).
PMID: 28605546
Study Objectives: Experimental evidence suggests that restorative processes depend on synaptic plasticity changes in the brain during sleep. We used the expression of plasticity-related genes to assess synaptic plasticity changes...