Thomas S Kilduff
Overview
Explore the profile of Thomas S Kilduff including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
83
Citations
2386
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Morairty S, Sun Y, Toll L, Bruchas M, Kilduff T
Proc Natl Acad Sci U S A
. 2023 Mar;
120(13):e2214171120.
PMID: 36947514
Sleep/wake control involves several neurotransmitter and neuromodulatory systems yet the coordination of the behavioral and physiological processes underlying sleep is incompletely understood. Previous studies have suggested that activation of the...
12.
Sun Y, Ranjan A, Tisdale R, Ma S, Park S, Haire M, et al.
J Sleep Res
. 2023 Feb;
32(4):e13839.
PMID: 36808670
The sleep disorder narcolepsy, a hypocretin deficiency disorder thought to be due to degeneration of hypothalamic hypocretin/orexin neurons, is currently treated symptomatically. We evaluated the efficacy of two small molecule...
13.
Sun Y, Tisdale R, Park S, Ma S, Heu J, Haire M, et al.
Sleep
. 2022 Feb;
45(12).
PMID: 35182424
Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been...
14.
Sun Y, Tisdale R, Kilduff T
Front Neurol Neurosci
. 2021 May;
45:22-37.
PMID: 34052813
The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G-protein-coupled receptors, HCRTR1/OX1R and HCRTR2/OX2R. Shortly after the...
15.
Barateau L, Jaussent I, Roeser J, Ciardiello C, Kilduff T, Dauvilliers Y
Sleep
. 2021 Jan;
44(7).
PMID: 33476396
Study Objectives: Whether the cause of daytime sleepiness in narcolepsy type 1 (NT1) is a direct consequence of the loss of orexin (ORX) neurons or whether low orexin reduces the...
16.
Tisdale R, Yamanaka A, Kilduff T
Sleep
. 2020 Dec;
44(6).
PMID: 33313880
Animal models have advanced not only our understanding of the etiology and phenotype of the sleep disorder narcolepsy but have also informed sleep/wake regulation more generally. The identification of an...
17.
Hung C, Ono D, Kilduff T, Yamanaka A
Elife
. 2020 Apr;
9.
PMID: 32314734
Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the hypothalamus and project throughout the brain to regulate sleep/wakefulness. Ablation of orexin neurons decreases wakefulness and results in a narcolepsy-like...
18.
Neylan T, Richards A, Metzler T, Ruoff L, Varbel J, ODonovan A, et al.
Sleep
. 2020 Apr;
43(10).
PMID: 32303763
Study Objectives: Hypnotic medications can adversely affect behavior during unanticipated awakenings during the night. Animals treated with the hypocretin (Hcrt) receptor antagonist almorexant (ALM) have less acute cognitive impairment compared...
19.
Regan M, Flynn-Evans E, Griko Y, Kilduff T, Rittenberger J, Ruskin K, et al.
J Appl Physiol (1985)
. 2020 Jan;
128(3):637-647.
PMID: 31999524
Synthetic torpor is an induced state of deep metabolic depression (MD) in an organism that does not naturally employ regulated and reversible MD. If applied to spaceflight crewmembers, this metabolic...
20.
Williams R, Tsunematsu T, Thomas A, Bogyo K, Yamanaka A, Kilduff T
J Neurosci
. 2019 Oct;
39(47):9435-9452.
PMID: 31628177
Narcolepsy, characterized by excessive daytime sleepiness, is associated with dysfunction of the hypothalamic hypocretin/orexin (Hcrt) system, either due to extensive loss of Hcrt cells (Type 1, NT1) or hypothesized Hcrt...