Takeshi Sakurai
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Explore the profile of Takeshi Sakurai including associated specialties, affiliations and a list of published articles.
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364
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12129
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Recent Articles
1.
Hikosaka M, Parvez M, Yamawaki Y, Oe S, Liang Y, Wada Y, et al.
Commun Biol
. 2025 Mar;
8(1):296.
PMID: 40033126
The functional alteration of microglia arises in brains exposed to external stress during early development. Pathophysiological findings of neurodevelopmental disorders such as schizophrenia and autism spectrum disorder suggest cerebellar functional...
2.
Masuda K, Yoshimoto R, Li R, Sakurai T, Hirano A
Nat Commun
. 2025 Feb;
16(1):1421.
PMID: 39915501
The phase response curve (PRC) represents the time-dependent changes in circadian rhythm phase following internal or external stimuli. However, this time dependence complicates PRC measurement and quantification owing to its...
3.
Furutani N, Saito Y, Niwa Y, Katsuyama Y, Nariya Y, Kikuchi M, et al.
Sci Rep
. 2025 Jan;
15(1):3080.
PMID: 39856071
We explore an innovative approach to sleep stage analysis by incorporating complexity features into sleep scoring methods for mice. Traditional sleep scoring relies on the power spectral features of electroencephalogram...
4.
Soya S, Toda K, Sakurai K, Cherasse Y, Saito Y, Abe M, et al.
Sci Adv
. 2025 Jan;
11(3):eadn1335.
PMID: 39813346
The formation of new social interactions is vital for social animals, but the underlying neural mechanisms remain poorly understood. We identified CeA neurons, a population in central amygdala expressing neuropeptide...
5.
Prefrontal synaptic regulation of homeostatic sleep pressure revealed through synaptic chemogenetics
Sawada T, Iino Y, Yoshida K, Okazaki H, Nomura S, Shimizu C, et al.
Science
. 2024 Sep;
385(6716):1459-1465.
PMID: 39325885
Sleep is regulated by homeostatic processes, yet the biological basis of sleep pressure that accumulates during wakefulness, triggers sleep, and dissipates during sleep remains elusive. We explored a causal relationship...
6.
Kashiwagi M, Beck G, Kanuka M, Arai Y, Tanaka K, Tatsuzawa C, et al.
Cell
. 2024 Sep;
187(22):6272-6289.e21.
PMID: 39303715
Identifying the properties of the rapid eye movement (REM) sleep circuitry and its relation to diseases has been challenging due to the neuronal heterogeneity of the brainstem. Here, we show...
7.
Masuda K, Sakurai T, Hirano A
Sci Rep
. 2024 Jul;
14(1):15479.
PMID: 38969743
Most organisms possess three biological oscillators, circadian clock, cell cycle, and redox rhythm, which are autonomous but interact each other. However, whether their interactions and autonomy are beneficial for organisms...
8.
Okuzono S, Fujii F, Setoyama D, Taira R, Shinmyo Y, Kato H, et al.
Genes Cells
. 2024 Jul;
29(9):746-756.
PMID: 38964745
An autism-associated gene Shank3 encodes multiple splicing isoforms, Shank3a-f. We have recently reported that Shank3a/b-knockout mice were more susceptible to kainic acid-induced seizures than wild-type mice at 4 weeks of...
9.
Nakai A, Kashiwagi M, Fujiyama T, Iwasaki K, Hirano A, Funato H, et al.
Mol Brain
. 2024 Feb;
17(1):13.
PMID: 38413970
The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss of function of the transcription factor AP-2β (TFAP2B) reduces non-rapid eye movement...
10.
Hasegawa E, Li Y, Sakurai T
Neurosci Res
. 2023 Sep;
200:28-33.
PMID: 37696450
Animals have a sleep cycle that involves the repetitive occurrence of non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. In a previous study, we discovered that a...