Thomas S Blacker
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Explore the profile of Thomas S Blacker including associated specialties, affiliations and a list of published articles.
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18
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1262
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Recent Articles
1.
OSullivan J, Blacker T, Scott C, Chang W, Ahmed M, Yianni V, et al.
Elife
. 2023 Aug;
12.
PMID: 37539863
In vertebrates with elongated auditory organs, mechanosensory hair cells (HCs) are organised such that complex sounds are broken down into their component frequencies along a proximal-to-distal long (tonotopic) axis. Acquisition...
2.
Esteras N, Blacker T, Zherebtsov E, Stelmashuk O, Zhang Y, Wigley W, et al.
Redox Biol
. 2023 Mar;
62:102672.
PMID: 36940606
The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by inducing expression of genes regulating cellular detoxification, antioxidant defence and energy metabolism. Energy production and antioxidant defence...
3.
Blacker T, Duchen M, Bain A
Biophys J
. 2023 Feb;
122(7):1240-1253.
PMID: 36793214
NADH and NADPH play key roles in the regulation of metabolism. Their endogenous fluorescence is sensitive to enzyme binding, allowing changes in cellular metabolic state to be determined using fluorescence...
4.
Chisholm D, Hughes J, Blacker T, Humann R, Adams C, Callaghan D, et al.
Org Biomol Chem
. 2020 Sep;
18(45):9231-9245.
PMID: 32966518
Fluorescent probes are increasingly used as reporter molecules in a wide variety of biophysical experiments, but when designing new compounds it can often be difficult to anticipate the effect that...
5.
Majumder P, Blacker T, Nolan L, Duchen M, Gale J
Sci Rep
. 2019 Dec;
9(1):18907.
PMID: 31827194
An increasing volume of data suggests that changes in cellular metabolism have a major impact on the health of tissues and organs, including in the auditory system where metabolic alterations...
6.
Thomas L, Esposito C, Stephen J, Costa A, Frezza C, Blacker T, et al.
Cancer Metab
. 2019 Jul;
7:7.
PMID: 31346464
Background: Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phenotypes through mechanisms that...
7.
Haythorne E, Rohm M, van de Bunt M, Brereton M, Tarasov A, Blacker T, et al.
Nat Commun
. 2019 Jun;
10(1):2474.
PMID: 31171772
Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to...
8.
Chisholm D, Lamb R, Pallett T, Affleck V, Holden C, Marrison J, et al.
Chem Sci
. 2019 May;
10(17):4673-4683.
PMID: 31123578
Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified...
9.
Blacker T, Nicolaou N, Duchen M, Bain A
J Phys Chem B
. 2019 Apr;
123(22):4705-4717.
PMID: 31021092
Two-photon absorption (2PA) finds widespread application in biological systems, which frequently exhibit heterogeneous fluorescence decay dynamics corresponding to multiple species or environments. By combining polarized 2PA with time-resolved fluorescence intensity...
10.
Blacker T, Sewell M, Szabadkai G, Duchen M
Methods Mol Biol
. 2019 Feb;
1928:365-387.
PMID: 30725465
Altered metabolism is a hallmark of cancer, both resulting from and driving oncogenesis. The NAD and NADP redox couples play a key role in a large number of the metabolic...