Photoactivated Cell-killing Involving a Low Molecular Weight, Donor-acceptor Diphenylacetylene

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 May 25

PMID 31123578

Citations 3

Authors

David R Chisholm

Rebecca Lamb

Tommy Pallett

Valerie Affleck

Claire Holden

Joanne Marrison

Peter OToole

Peter D Ashton

Katherine Newling

Andreas Steffen

Amanda K Nelson

Christoph Mahler

Roy Valentine

Thomas S Blacker

Angus J Bain

John Girkin

Todd B Marder

Andrew Whiting

Carrie A Ambler

Affiliations

Soon will be listed here.

Abstract

Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by , has been designed possessing a modular, low molecular weight and 'drug-like' structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of cellular assays confirmed ROS formation and cytotoxic activity was exemplified irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.

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