Jonathan E Gale
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Explore the profile of Jonathan E Gale including associated specialties, affiliations and a list of published articles.
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32
Citations
1419
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Recent Articles
1.
Martin J, Terry S, Gale J, Dawson S
J Cell Sci
. 2023 Jun;
136(14).
PMID: 37334742
Cisplatin is an effective platinum-based chemotherapeutic with several side effects, including ototoxicity. Cochlear cells have low rates of proliferation yet are highly susceptible to cisplatin. We hypothesised that cisplatin ototoxicity...
2.
Martin J, Dawson S, Gale J
Hear Res
. 2022 Nov;
426:108634.
PMID: 36384053
Stress granules (SGs) are membrane-less cytosolic assemblies that form in response to stress (e.g., heat, oxidative stress, hypoxia, viral infection and UV). Composed of mRNA, RNA binding proteins and signalling...
3.
Nolan L, Chen J, Goncalves A, Bullen A, Towers E, Steel K, et al.
Sci Rep
. 2022 Feb;
12(1):2444.
PMID: 35165318
Cell cycle associated protein 1 (Caprin1) is an RNA-binding protein that can regulate the cellular post-transcriptional response to stress. It is a component of both stress granules and neuronal RNA...
4.
Gomez-Dorado M, Daudet N, Gale J, Dawson S
Sci Rep
. 2021 Sep;
11(1):19368.
PMID: 34588543
The mammalian inner ear has a limited capacity to regenerate its mechanosensory hair cells. This lack of regenerative capacity underlies the high incidence of age-related hearing loss in humans. In...
5.
Prades S, Heard G, Gale J, Engel T, Kopp R, Nicke A, et al.
J Neurosci
. 2021 Feb;
41(12):2615-2629.
PMID: 33563723
P2X receptors (P2XRs) are associated with numerous pathophysiological mechanisms, and this promotes them as therapeutic targets for certain neurodegenerative conditions. However, the identity of P2XR-expressing cells in the nervous system...
6.
Keder A, Tardieu C, Malong L, Filia A, Kashkenbayeva A, Newton F, et al.
Sci Rep
. 2020 May;
10(1):7431.
PMID: 32366993
Age-related hearing loss (ARHL) is a threat to future human wellbeing. Multiple factors contributing to the terminal auditory decline have been identified; but a unified understanding of ARHL - or...
7.
Majumder P, Blacker T, Nolan L, Duchen M, Gale J
Sci Rep
. 2019 Dec;
9(1):18907.
PMID: 31827194
An increasing volume of data suggests that changes in cellular metabolism have a major impact on the health of tissues and organs, including in the auditory system where metabolic alterations...
8.
Goncalves A, Towers E, Haq N, Porco Jr J, Pelletier J, Dawson S, et al.
Sci Rep
. 2019 Aug;
9(1):12501.
PMID: 31467369
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative...
9.
Sirko P, Gale J, Ashmore J
J Physiol
. 2018 Oct;
597(1):303-317.
PMID: 30318615
Key Points: Intercellular Ca waves are increases in cytoplasmic Ca levels that propagate between cells. Periodic Ca waves have been linked to gene regulation and are thought to play a...
10.
Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine's Potential
Majumder P, Moore P, Richardson G, Gale J
Front Cell Neurosci
. 2017 May;
11:94.
PMID: 28503132
Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic, causing the death of sensory hair cells in...