Thomas R Bauer Jr
Overview
Explore the profile of Thomas R Bauer Jr including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
248
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Recent Articles
1.
Zoto A, Stecklein C, Scott M, Bauer Jr T, Lucidi C, Cridge H
J Vet Intern Med
. 2022 Oct;
36(6):2170-2176.
PMID: 36239343
Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We...
2.
Smith R, Bloomer H, Fink D, Keyvanfar K, Nasimuzzaman M, Sancheznieto F, et al.
Hum Gene Ther
. 2022 Sep;
33(23-24):1293-1304.
PMID: 36094106
gene therapy procedures targeting hematopoietic stem and progenitor cells (HSPCs) predominantly utilize lentivirus-based vectors for gene transfer. We provide the first pre-clinical evidence of the therapeutic utility of a foamy...
3.
Nichols-Vinueza D, Parta M, Shah N, Cuellar-Rodriguez J, Bauer Jr T, West R, et al.
Br J Haematol
. 2021 Sep;
196(1):169-178.
PMID: 34580862
GATA2 deficiency was described in 2011, and shortly thereafter allogeneic hematopoietic stem cell transplantation (HSCT) was shown to reverse the hematologic disease phenotype. However, there remain major unanswered questions regarding...
4.
Bauer Jr T, Pratt S, Palena C, Raj K, Giger U
Vet Clin Pathol
. 2017 Jul;
46(3):391-400.
PMID: 28750142
Background: Leukocyte adhesion deficiency (LAD) or CD18 deficiency is an autosomal recessive immunodeficiency which has been described in people, cattle, dogs, and knockout mice. Objectives: The study goals were to...
5.
Bauer Jr T, Tuschong L, Calvo K, Shive H, Burkholder T, Karlsson E, et al.
Mol Ther
. 2013 Mar;
21(5):964-72.
PMID: 23531552
The development of leukemia following gammaretroviral vector-mediated gene therapy for X-linked severe combined immunodeficiency disease and chronic granulomatous disease (CGD) has emphasized the need for long-term follow-up in animals treated...
6.
Donahue R, Tuschong L, Bauer Jr T, Yau Y, Leitman S, Hickstein D
Blood
. 2011 Aug;
118(15):4209-14.
PMID: 21844566
After administration of granulocyte colony-stimulating factor (G-CSF), there is a marked, albeit transient, drop in circulating neutrophils. To determine the role of leukocyte integrins in this disappearance, a dog having...
7.
Hunter M, Zhao H, Tuschong L, Bauer Jr T, Burkholder T, Persons D, et al.
Hum Gene Ther
. 2011 Feb;
22(6):689-96.
PMID: 21275758
Children with leukocyte adhesion deficiency type 1 (LAD-1) and dogs with canine LAD (CLAD) develop life-threatening bacterial infections due to mutations in the leukocyte integrin CD18. Here, we compared the...
8.
Hunter M, Tuschong L, Fowler C, Bauer Jr T, Burkholder T, Hickstein D
Mol Ther
. 2010 Sep;
19(1):113-21.
PMID: 20859258
To identify cellular promoters in a self-inactivating (SIN) lentiviral vector that might be beneficial in treating children with leukocyte adhesion deficiency type 1 (LAD-1), we tested lentiviral vectors with human...
9.
Ohmine K, Li Y, Bauer Jr T, Hickstein D, Russell D
Hum Gene Ther
. 2010 Aug;
22(2):217-24.
PMID: 20738155
Vector integration can lead to proto-oncogene activation and malignancies during hematopoietic stem cell gene therapy. We previously used foamy virus vectors to deliver the CD18 gene under the control of...
10.
Bauer Jr T, Adler R, Hickstein D
ILAR J
. 2009 Mar;
50(2):168-86.
PMID: 19293460
Genetic mutations involving the cellular components of the hematopoietic system--red blood cells, white blood cells, and platelets--manifest clinically as anemia, infection, and bleeding. Although gene targeting has recapitulated many of...