David C Rubinsztein
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Explore the profile of David C Rubinsztein including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Fleming A, Lopez A, Rob M, Ramakrishna S, Park S, Li X, et al.
Neuroscientist
. 2025 Mar;
:10738584251324459.
PMID: 40079405
Autophagies describe a set of processes in which cells degrade their cytoplasmic contents via various routes that terminate with the lysosome. In macroautophagy (the focus of this review, henceforth autophagy),...
2.
Zhu Y, Fujimaki M, Rubinsztein D
Trends Cell Biol
. 2025 Mar;
PMID: 40050185
Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which...
3.
Lopez A, Siddiqi F, Villeneuve J, Ureshino R, Jeon H, Koulousakis P, et al.
Nat Chem Biol
. 2024 Nov;
PMID: 39482469
Tauopathies are neurodegenerative diseases that manifest with intracellular accumulation and aggregation of tau protein. These include Pick's disease, progressive supranuclear palsy, corticobasal degeneration and argyrophilic grain disease, where tau is...
4.
Keshri S, Vicinanza M, Takla M, Rubinsztein D
Cell Rep
. 2024 Oct;
43(11):114872.
PMID: 39412987
The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy. We identify a distinct nuclear interactome of TFEB, with ubiquitin-specific protease 7 (USP7) emerging as a...
5.
Palmer J, Wilson N, Son S, Obrocki P, Wrobel L, Rob M, et al.
Neuron
. 2024 Oct;
113(1):29-48.
PMID: 39406236
Autophagy is a conserved mechanism that degrades damaged or superfluous cellular contents and enables nutrient recycling under starvation conditions. Many neurodegeneration-associated proteins are autophagy substrates, and autophagy upregulation ameliorates disease...
6.
Park S, Son S, Barbosa A, Wrobel L, Stamatakou E, Squitieri F, et al.
Nat Cell Biol
. 2024 Aug;
26(10):1691-1699.
PMID: 39209961
Autophagy is a conserved pathway where cytoplasmic contents are engulfed by autophagosomes, which then fuse with lysosomes enabling their degradation. Mutations in core autophagy genes cause neurological conditions, and autophagy...
7.
Neel E, Chiritoiu-Butnaru M, Fargues W, Denus M, Colladant M, Filaquier A, et al.
J Cell Biol
. 2024 Aug;
223(9).
PMID: 39133205
Most secreted proteins are transported through the "conventional" endoplasmic reticulum-Golgi apparatus exocytic route for their delivery to the cell surface and release into the extracellular space. Nonetheless, formative discoveries have...
8.
Nixon R, Rubinsztein D
Nat Rev Mol Cell Biol
. 2024 Aug;
25(11):926-946.
PMID: 39107446
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and aggregate-prone proteins. Their postmitotic nature and extremely polarized morphologies make neurons particularly vulnerable...
9.
Yu Z, Carmichael J, Collins G, DAgostino M, Lessard M, Firth H, et al.
Hum Mol Genet
. 2024 May;
33(17):1506-1523.
PMID: 38776958
The ubiquitin-proteasome system mediates the degradation of a wide variety of proteins. Proteasome dysfunction is associated with neurodegenerative diseases and neurodevelopmental disorders in humans. Here we identified mutations in PSMC5,...
10.
Wrobel L, Hoffmann J, Li X, Rubinsztein D
Sci Adv
. 2024 May;
10(18):eadl6082.
PMID: 38701207
The AAA-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), a major protein unfolding machinery with a variety of essential functions, localizes to different subcellular compartments where it has different...