Thomas P Neufeld
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Explore the profile of Thomas P Neufeld including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Braden C, Neufeld T
FEBS J
. 2016 Oct;
283(21):3889-3897.
PMID: 27717182
Although canonical autophagy regulation requires a multi-protein complex centered on the Ser/Thr-kinase Atg1 (mammalian Ulk1/2), alternative signals can induce autophagy independent of Atg1 through unknown mechanisms. Here we identify the...
12.
Mauvezin C, Neufeld T
Small GTPases
. 2016 May;
8(1):16-19.
PMID: 27142690
The intracellular movement of membrane-bound vesicles is closely tied to their formation, maturation and ultimate function within the cell. Motor proteins and their associated cytoskeletal networks are critical for vesicle...
13.
Mauvezin C, Neisch A, Ayala C, Kim J, Beltrame A, Braden C, et al.
J Cell Sci
. 2016 Jan;
129(5):971-82.
PMID: 26763909
Degradation of cellular material by autophagy is essential for cell survival and homeostasis, and requires intracellular transport of autophagosomes to encounter acidic lysosomes through unknown mechanisms. Here, we identify the...
14.
Jin A, Neufeld T, Choe J
Biochem Biophys Res Commun
. 2015 Nov;
468(1-2):1-7.
PMID: 26551466
Autophagy is a bulk degradation system that functions in response to cellular stresses such as metabolic stress, endoplasmic reticulum stress, oxidative stress, and developmental processes. During autophagy, cytoplasmic components are...
15.
Mauvezin C, Neufeld T
Autophagy
. 2015 Jul;
11(8):1437-8.
PMID: 26156798
Autophagosome-lysosome fusion and autolysosome acidification constitute late steps in the autophagic process necessary to maintain functional autophagic flux and cellular homeostasis. Both of these steps are disrupted by the V-ATPase...
16.
Mauvezin C, Nagy P, Juhasz G, Neufeld T
Nat Commun
. 2015 May;
6:7007.
PMID: 25959678
The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to...
17.
Kim J, Neufeld T
Nat Commun
. 2015 Apr;
6:6846.
PMID: 25882208
Secreted ligands of the insulin family promote cell growth and maintain sugar homeostasis. Insulin release is tightly regulated in response to dietary conditions, but how insulin-producing cells (IPCs) coordinate their...
18.
Neufeld T, Hariharan I
Results Probl Cell Differ
. 2015 Feb;
37:107-33.
PMID: 25707072
No abstract available.
19.
Mauvezin C, Ayala C, Braden C, Kim J, Neufeld T
Methods
. 2014 Mar;
68(1):134-9.
PMID: 24667416
The term autophagy refers to the engulfment and degradation of cytoplasmic components within the lysosome. This process can benefit cells and organisms by removing damaged, superfluous, or harmful cellular components,...
20.
Knaevelsrud H, Soreng K, Raiborg C, Haberg K, Rasmuson F, Brech A, et al.
J Cell Biol
. 2013 Jul;
202(2):331-49.
PMID: 23878278
The membrane remodeling events required for autophagosome biogenesis are still poorly understood. Because PX domain proteins mediate membrane remodeling and trafficking, we conducted an imaging-based siRNA screen for autophagosome formation...