Thomas M Huckaba
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Explore the profile of Thomas M Huckaba including associated specialties, affiliations and a list of published articles.
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12
Citations
410
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Recent Articles
1.
Bornes K, Moody M, Huckaba T, Benz M, McConnell E, Foroozesh M, et al.
FEBS Open Bio
. 2024 Nov;
15(1):94-107.
PMID: 39482806
Lysine deacetylases (KDACs or HDACs) are metal-dependent enzymes that regulate lysine acetylation, a post-translational modification that is present on thousands of human proteins, essential for many cellular processes, and often...
2.
Sing C, Garcia E, Lipkin T, Huckaba T, Tsang C, Coughlin A, et al.
Nat Commun
. 2022 May;
13(1):2706.
PMID: 35577788
In yeast, actin cables are F-actin bundles that are essential for cell division through their function as tracks for cargo movement from mother to daughter cell. Actin cables also affect...
3.
Crawford L, Bart Jr H, Harold E, Huckaba T, Davenport I
J Fish Biol
. 2020 Jun;
97(3):691-695.
PMID: 32506516
Follicle cell processes (FCP) are actin-based, tube-like structures that connect the developing oocyte to the follicle cells throughout oogenesis. They were first described in Selachians (sharks) where their suggested roles...
4.
Maziveyi M, Dong S, Baranwal S, Mehrnezhad A, Rathinam R, Huckaba T, et al.
Cancer Res
. 2019 Jan;
79(9):2152-2166.
PMID: 30635277
Exosomes are small extracellular microvesicles that are secreted by cells when intracellular multivesicular bodies fuse with the plasma membrane. We have previously demonstrated that Nischarin inhibits focal adhesion formation, cell...
5.
Jennings S, Chenevert M, Liu L, Mottamal M, Wojcik E, Huckaba T
PLoS One
. 2017 Jul;
12(7):e0180353.
PMID: 28678816
Kif5A is a neuronally-enriched isoform of the Kinesin-1 family of cellular transport motors. 23 separate mutations in the motor domain of Kif5A have been identified in patients with the complicated...
6.
Wojcik E, Buckley R, Richard J, Liu L, Huckaba T, Kim S
Gene
. 2013 Aug;
531(2):133-49.
PMID: 23954229
Kinesin motor proteins comprise an ATPase superfamily that works hand in hand with microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic role in cancerous cells,...
7.
Huckaba T, Gennerich A, Wilhelm J, Chishti A, Vale R
J Biol Chem
. 2010 Dec;
286(9):7457-67.
PMID: 21169635
Drosophila Kinesin-73 (Khc-73), which plays a role in mitotic spindle polarity in neuroblasts, is a metazoan-specific member of the Kinesin-3 family of motors, which includes mammalian KIF1A and Caenorhabditis elegans...
8.
Huckaba T, Lipkin T, Pon L
J Cell Biol
. 2006 Dec;
175(6):957-69.
PMID: 17178912
Retrograde flow of cortical actin networks and bundles is essential for cell motility and retrograde intracellular movement, and for the formation and maintenance of microvilli, stereocilia, and filopodia. Actin cables,...
9.
Eng C, Huckaba T, Gundersen G
Mol Biol Cell
. 2006 Sep;
17(12):5004-16.
PMID: 16987962
In migrating cells, external signals polarize the microtubule (MT) cytoskeleton by stimulating the formation of oriented, stabilized MTs and inducing the reorientation of the MT organizing center (MTOC). Glycogen synthase...
10.
Fehrenbacher K, Yang H, Gay A, Huckaba T, Pon L
Curr Biol
. 2004 Nov;
14(22):1996-2004.
PMID: 15556861
Background: Mitochondrial inheritance is essential for cell division. In budding yeast, mitochondrial movement from mother to daughter requires (1) actin cables, F-actin bundles that undergo retrograde movement during elongation from...