Edward J Wojcik
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Explore the profile of Edward J Wojcik including associated specialties, affiliations and a list of published articles.
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13
Citations
232
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Recent Articles
1.
Liu L, Downs M, Guidry J, Wojcik E
iScience
. 2021 May;
24(5):102385.
PMID: 33997675
Here we identify human Kinesin-5, Kif11/HsEg5, as a cellular target of Zika protease. We show that Zika NS2B-NS3 protease targets several sites within the motor domain of HsEg5 irrespective of...
2.
Kim C, Kim E, Liu L, Buckley R, Parameswaran S, Kim S, et al.
Sci Rep
. 2019 Dec;
9(1):19900.
PMID: 31882607
Human Kinesin-5 (Eg5) has a large number of known allosteric inhibitors that disrupt its mitotic function. Small-molecule inhibitors of Eg5 are candidate anti-cancer agents and important probes for understanding the...
3.
Cardenas D, Sylvester C, Cao B, Nation C, Pizarro J, Lu H, et al.
mSphere
. 2019 Mar;
4(2).
PMID: 30842271
During their parasitic life cycle, through sandflies and vertebrate hosts, parasites confront strikingly different environments, including abrupt changes in pH and temperature, to which they must rapidly adapt. These adaptations...
4.
Jennings S, Chenevert M, Liu L, Mottamal M, Wojcik E, Huckaba T
PLoS One
. 2017 Jul;
12(7):e0180353.
PMID: 28678816
Kif5A is a neuronally-enriched isoform of the Kinesin-1 family of cellular transport motors. 23 separate mutations in the motor domain of Kif5A have been identified in patients with the complicated...
5.
Liu L, Richard J, Kim S, Wojcik E
J Biol Chem
. 2014 Apr;
289(23):16601-14.
PMID: 24737313
Plasmodium falciparum and vivax are responsible for the majority of malaria infections worldwide, resulting in over a million deaths annually. Malaria parasites now show measured resistance to all currently utilized...
6.
Wojcik E, Buckley R, Richard J, Liu L, Huckaba T, Kim S
Gene
. 2013 Aug;
531(2):133-49.
PMID: 23954229
Kinesin motor proteins comprise an ATPase superfamily that works hand in hand with microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic role in cancerous cells,...
7.
Liu L, Parameswaran S, Liu J, Kim S, Wojcik E
J Biol Chem
. 2010 Dec;
286(8):6201-10.
PMID: 21127071
The human Eg5 (HsEg5) protein is unique in its sensitivity to allosteric agents even among phylogenetic kin. For example, S-trityl-l-cysteine (STC) and monastrol are HsEg5 inhibitors that bind to a...
8.
Kim E, Buckley R, Learman S, Richard J, Parke C, Worthylake D, et al.
J Biol Chem
. 2010 Mar;
285(24):18650-61.
PMID: 20299460
Essential in mitosis, the human Kinesin-5 protein is a target for >80 classes of allosteric compounds that bind to a surface-exposed site formed by the L5 loop. Not established is...
9.
Parke C, Wojcik E, Kim S, Worthylake D
J Biol Chem
. 2009 Dec;
285(8):5859-67.
PMID: 20018897
Motor proteins couple steps in ATP binding and hydrolysis to conformational switching both in and remote from the active site. In our kinesin.AMPPPNP crystal structure, closure of the active site...
10.
Learman S, Kim C, Stevens N, Kim S, Wojcik E, Walker R
Biochemistry
. 2009 Feb;
48(8):1754-62.
PMID: 19236100
Kinesin-5 proteins are essential for formation of a bipolar mitotic spindle in most and, perhaps all, eukaryotic cells. Several Kinesin-5 proteins, notably the human version, HsEg5, are targets of a...