Thomas L Schwarz
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Explore the profile of Thomas L Schwarz including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Davis K, Basu H, Izquierdo-Villalba I, Shurberg E, Schwarz T
Life Sci Alliance
. 2022 Oct;
6(1).
PMID: 36302649
Mitochondrial transport relies on a motor-adaptor complex containing Miro1, a mitochondrial outer membrane protein with two GTPase domains, and TRAK1/2, kinesin-1, and dynein. Using a peroxisome-directed Miro1, we quantified the...
2.
Rohban M, Fuller A, Tan C, Goldstein J, Syangtan D, Gutnick A, et al.
Cell Syst
. 2022 Sep;
13(9):724-736.e9.
PMID: 36057257
Identifying the chemical regulators of biological pathways is a time-consuming bottleneck in developing therapeutics and research compounds. Typically, thousands to millions of candidate small molecules are tested in target-based biochemical...
3.
Harbauer A, Schwarz T
Autophagy
. 2022 Apr;
18(12):3048-3049.
PMID: 35470750
Mitostasis, the process of mitochondrial maintenance by biogenesis and degradative mechanisms, is challenged by the extreme length of axons. PINK1 (PTEN induced putative kinase 1) is a mitochondrial protein that...
4.
Heo K, Basu H, Gutnick A, Wei W, Shlevkov E, Schwarz T
Front Cell Neurosci
. 2022 Apr;
16:852245.
PMID: 35370563
Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening...
5.
Harbauer A, Hees J, Wanderoy S, Segura I, Gibbs W, Cheng Y, et al.
Neuron
. 2022 Feb;
110(9):1516-1531.e9.
PMID: 35216662
PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to...
6.
Wu C, Vinton E, Pearse 2nd R, Heo K, Aylward A, Hsieh Y, et al.
Mol Psychiatry
. 2022 Feb;
27(4):1970-1989.
PMID: 35194165
Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer's disease (AD). Here, we used human induced pluripotent stem cells (hiPSCs) along with CRISPR-Cas9 gene editing to investigate...
7.
Basu H, Pekkurnaz G, Falk J, Wei W, Chin M, Steen J, et al.
J Cell Biol
. 2021 Aug;
220(10).
PMID: 34342639
Mitochondrial movement and distribution are fundamental to their function. Here we report a mechanism that regulates mitochondrial movement by anchoring mitochondria to the F-actin cytoskeleton. This mechanism is activated by...
8.
Bourke A, Schwartz S, Bowen A, Kleinjan M, Winborn C, Kareemo D, et al.
J Cell Biol
. 2021 Jul;
220(9).
PMID: 34241635
Here we introduce zapalog-mediated endoplasmic reticulum trap (zapERtrap), which allows one to use light to precisely trigger forward trafficking of diverse integral membrane proteins from internal secretory organelles to the...
9.
10.
Basu H, Schwarz T
Curr Protoc Cell Biol
. 2020 Jun;
87(1):e108.
PMID: 32569415
Trafficking of intracellular cargo is essential to cellular function and can be defective in pathological states including cancer and neurodegeneration. Tools to quantify intracellular traffic are thus necessary for understanding...