Thomas L Saunders
Overview
Explore the profile of Thomas L Saunders including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
116
Citations
5038
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Paul M, Chen D, Vish K, Lartey N, Hughes E, Freeman Z, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2418433122.
PMID: 39899710
Regulation of Ras GTPases by GTPase-activating proteins (GAPs) is essential for their normal signaling. Nine of the ten GAPs for Ras contain a C2 domain immediately proximal to their canonical...
2.
Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A, prevents excessive synaptogenesis
Nagai M, Porter R, Miyasato M, Wang A, Gavilan C, Hughes E, et al.
J Biol Chem
. 2024 Oct;
300(11):107881.
PMID: 39395799
PHF21A is a histone-binding protein that recognizes unmethylated histone H3K4, the reaction product of LSD1 histone demethylase. PHF21A and LSD1 form a complex, and both undergo neuron-specific microexon splicing. The...
3.
Cavanaugh B, Milstein M, Boucher R, Tan S, Hanna M, Seidel A, et al.
Hum Mol Genet
. 2024 Sep;
33(21):1916-1928.
PMID: 39231530
Mutations in PRPH2 are a relatively common cause of sight-robbing inherited retinal degenerations (IRDs). Peripherin-2 (PRPH2) is a photoreceptor-specific tetraspanin protein that structures the disk rim membranes of rod and...
4.
Ubogu E, Conner J, Wang Y, Yadav D, Saunders T
Muscle Nerve
. 2024 Jun;
70(3):420-433.
PMID: 38922958
Introduction/aims: The precise relationship between molecular mimicry and tissue-specific autoimmunity is unknown. Major histocompatibility complex (MHC) class II antigen presenting cell-CD4+ T-cell receptor complex interactions are necessary for adaptive immunity....
5.
Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, et al.
iScience
. 2024 Jun;
27(6):109991.
PMID: 38846003
SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the...
6.
Nagai M, Porter R, Hughes E, Saunders T, Iwase S
bioRxiv
. 2024 Apr;
PMID: 38562691
LSD1 histone H3K4 demethylase and its binding partner PHF21A, a reader protein for unmethylated H3K4, both undergo neuron-specific microexon splicing. The LSD1 neuronal microexon weakens H3K4 demethylation activity and can...
7.
Yadav D, Conner J, Wang Y, Saunders T, Ubogu E
Vascul Pharmacol
. 2024 Mar;
155:107369.
PMID: 38554988
Mouse models are invaluable to understanding fundamental mechanisms in vascular biology during development, in health and different disease states. Several constitutive or inducible models that selectively knockout or knock in...
8.
Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, et al.
bioRxiv
. 2023 Dec;
PMID: 38105987
SIRT5 is a sirtuin deacylase that represents the major activity responsible for removal of negatively-charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and...
9.
Chen J, Zhang L, Yang M, Hughes E, Freeman Z, Saunders T, et al.
J Innate Immun
. 2023 Nov;
16(1):56-65.
PMID: 38035563
Introduction: C3 is central for all complement activation pathways, thus making it an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use....
10.
Kim J, Villa-Diaz L, Saunders T, Saul R, Timilsina S, Liu F, et al.
Stem Cells
. 2023 Nov;
42(1):13-28.
PMID: 37931173
Insight into the molecular mechanisms governing the development and maintenance of pluripotency is important for understanding early development and the use of stem cells in regenerative medicine. We demonstrate the...