Thomas J Nicholls
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Explore the profile of Thomas J Nicholls including associated specialties, affiliations and a list of published articles.
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26
Citations
943
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Recent Articles
1.
Bernardino Gomes T, Vincent A, Menger K, Stewart J, Nicholls T
Biochem J
. 2024 May;
481(11):683-715.
PMID: 38804971
Human mitochondria possess a multi-copy circular genome, mitochondrial DNA (mtDNA), that is essential for cellular energy metabolism. The number of copies of mtDNA per cell, and their integrity, are maintained...
2.
Erdinc D, Rodriguez-Luis A, Fassad M, Mackenzie S, Watson C, Valenzuela S, et al.
EMBO Mol Med
. 2023 Apr;
15(5):e16775.
PMID: 37013609
Topoisomerase 3α (TOP3A) is an enzyme that removes torsional strain and interlinks between DNA molecules. TOP3A localises to both the nucleus and mitochondria, with the two isoforms playing specialised roles...
3.
Menger K, Nicholls T
Methods Mol Biol
. 2023 Feb;
2615:17-30.
PMID: 36807781
Mitochondria are double membrane-bound eukaryotic organelles with roles in a range of cellular activities including energy conversion, apoptosis, cell signalling, and the biosynthesis of enzyme cofactors. Mitochondria contain their own...
4.
Menger K, Chapman J, Diaz-Maldonado H, Khazeem M, Deen D, Erdinc D, et al.
Nucleic Acids Res
. 2022 Oct;
50(19):11154-11174.
PMID: 36215039
Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated the subcellular localisation and activity of the six...
5.
Tan B, Mutti C, Shi Y, Xie X, Zhu X, Silva-Pinheiro P, et al.
Mol Cell
. 2022 Aug;
82(19):3646-3660.e9.
PMID: 36044900
The human mitochondrial genome must be replicated and expressed in a timely manner to maintain energy metabolism and supply cells with adequate levels of adenosine triphosphate. Central to this process...
6.
Misic J, Milenkovic D, Al-Behadili A, Xie X, Jiang M, Jiang S, et al.
Nucleic Acids Res
. 2022 Aug;
50(15):8749-8766.
PMID: 35947649
The in vivo role for RNase H1 in mammalian mitochondria has been much debated. Loss of RNase H1 is embryonic lethal and to further study its role in mtDNA expression...
7.
Menger K, Rodriguez-Luis A, Chapman J, Nicholls T
Open Biol
. 2021 Sep;
11(9):210168.
PMID: 34547213
The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at thousands of copies per human cell. MtDNA is packaged into nucleoprotein complexes called nucleoids, and the...
8.
Jiang M, Xie X, Zhu X, Jiang S, Milenkovic D, Misic J, et al.
Sci Adv
. 2021 Jul;
7(27).
PMID: 34215584
We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria. Transcription from the light-strand promoter (LSP) is required...
9.
Chapman J, Ng Y, Nicholls T
Life (Basel)
. 2020 Aug;
10(9).
PMID: 32858900
Mitochondria are complex organelles that harbour their own genome. Mitochondrial DNA (mtDNA) exists in the form of a circular double-stranded DNA molecule that must be replicated, segregated and distributed around...
10.
Strakova A, Nicholls T, Baez-Ortega A, Ni Leathlobhair M, Sampson A, Hughes K, et al.
Nat Commun
. 2020 Jun;
11(1):3059.
PMID: 32546718
Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However,...