Aleksandra Filipovska
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Explore the profile of Aleksandra Filipovska including associated specialties, affiliations and a list of published articles.
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123
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3611
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Recent Articles
1.
Bond S, King E, Walker S, Yang C, Liu Y, Liu K, et al.
Nat Commun
. 2025 Mar;
16(1):2338.
PMID: 40057508
During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses to preserve cellular health. One such pathway is the mitochondrial integrated stress response (mtISR), which...
2.
Yang X, Stentenbach M, Hughes L, Siira S, Lau K, Hothorn M, et al.
Nucleic Acids Res
. 2024 Dec;
53(4).
PMID: 39727163
Expression of the compact mitochondrial genome is regulated by nuclear encoded, mitochondrially localized RNA-binding proteins (RBPs). RBPs regulate the lifecycles of mitochondrial RNAs from transcription to degradation by mediating RNA...
3.
Gandadireja A, Vos P, Siira S, Filipovska A, Rackham O
ACS Synth Biol
. 2024 Sep;
13(10):3128-3136.
PMID: 39298405
Base editing technologies enable programmable single-nucleotide changes in target DNA without double-stranded DNA breaks. Adenine base editors (ABEs) allow precise conversion of adenine (A) to guanine (G). However, limited availability...
4.
Lee R, Rudler D, Rackham O, Filipovska A
Trends Endocrinol Metab
. 2024 Jul;
35(10):872-883.
PMID: 38972781
The presence of membrane-bound organelles with specific functions is one of the main hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that govern their function and interorganelle...
5.
Rackham O, Saurer M, Ban N, Filipovska A
Trends Cell Biol
. 2024 Jun;
35(1):11-23.
PMID: 38853081
Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has given rise to unique...
6.
Hughes L, Rackham O, Filipovska A
Hum Mol Genet
. 2024 May;
33(R1):R61-R79.
PMID: 38779771
Mitochondria are hubs of metabolic activity with a major role in ATP conversion by oxidative phosphorylation (OXPHOS). The mammalian mitochondrial genome encodes 11 mRNAs encoding 13 OXPHOS proteins along with...
7.
Vos P, Gandadireja A, Rossetti G, Siira S, Mantegna J, Filipovska A, et al.
Cell Rep Methods
. 2024 Apr;
4(4):100756.
PMID: 38608689
Programmable DNA endonucleases derived from bacterial genetic defense systems, exemplified by CRISPR-Cas9, have made it significantly easier to perform genomic modifications in living cells. However, unprogrammed, off-target modifications can have...
8.
Lee R, Rudler D, Raven S, Peng L, Chopin A, Moh E, et al.
Nat Cell Biol
. 2023 Dec;
26(1):57-71.
PMID: 38129691
The structures and functions of organelles in cells depend on each other but have not been systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and endoplasmic reticulum...
9.
Richman T, Ermer J, Baker J, Siira S, Kile B, Linden M, et al.
Cell Rep
. 2023 Oct;
42(11):113312.
PMID: 37889747
Platelets are anucleate blood cells that contain mitochondria and regulate blood clotting in response to injury. Mitochondria contain their own gene expression machinery that relies on nuclear-encoded factors for the...
10.
Uoselis L, Lindblom R, Lam W, Kung C, Skulsuppaisarn M, Khuu G, et al.
Sci Adv
. 2023 Sep;
9(38):eadh8228.
PMID: 37738349
Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPR) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited...