Thomas J Macartney
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Explore the profile of Thomas J Macartney including associated specialties, affiliations and a list of published articles.
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31
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1653
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Recent Articles
11.
Simpson L, Macartney T, Nardin A, Fulcher L, Roth S, Testa A, et al.
Cell Chem Biol
. 2020 Jul;
27(9):1164-1180.e5.
PMID: 32668203
The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI....
12.
Roth S, Macartney T, Konopacka A, Chan K, Zhou H, Queisser M, et al.
Cell Chem Biol
. 2020 Jul;
27(9):1151-1163.e6.
PMID: 32668202
K-RAS is known as the most frequently mutated oncogene. However, the development of conventional K-RAS inhibitors has been extremely challenging, with a mutation-specific inhibitor reaching clinical trials only recently. Targeted...
13.
Tachie-Menson T, Gazquez-Gutierrez A, Fulcher L, Macartney T, Wood N, Varghese J, et al.
Cell Signal
. 2020 Apr;
72:109632.
PMID: 32289446
The majority of mutations identified in patients with amelogenesis imperfecta have been mapped to FAM83H. As FAM83H expression is not limited to the enamel, how FAM83H contributes to amelogenesis is...
14.
Bozic M, van den Bekerom L, Milne B, Goodman N, Roberston L, Prescott A, et al.
EMBO Rep
. 2020 Feb;
21(3):e48412.
PMID: 32009292
The intracellular trafficking pathway, macroautophagy, is a recycling and disposal service that can be upregulated during periods of stress to maintain cellular homeostasis. An essential phase is the elongation and...
15.
Wu K, Jones R, Tachie-Menson T, Macartney T, Wood N, Varghese J, et al.
Wellcome Open Res
. 2019 Oct;
4:133.
PMID: 31656861
Two recessive mutations in the gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and...
16.
Fulcher L, He Z, Mei L, Macartney T, Wood N, Prescott A, et al.
EMBO Rep
. 2019 Jul;
20(9):e47495.
PMID: 31338967
The concerted action of many protein kinases helps orchestrate the error-free progression through mitosis of mammalian cells. The roles and regulation of some prominent mitotic kinases, such as cyclin-dependent kinases,...
17.
Fulcher L, Bozatzi P, Tachie-Menson T, Wu K, Cummins T, Bufton J, et al.
Sci Signal
. 2018 May;
11(531).
PMID: 29789297
Members of the casein kinase 1 (CK1) family of serine-threonine protein kinases are implicated in the regulation of many cellular processes, including the cell cycle, circadian rhythms, and Wnt and...
18.
Bozatzi P, Dingwell K, Wu K, Cooper F, Cummins T, Hutchinson L, et al.
EMBO Rep
. 2018 Mar;
19(4).
PMID: 29514862
The BMP and Wnt signalling pathways determine axis specification during embryonic development. Our previous work has shown that PAWS1 (also known as FAM83G) interacts with SMAD1 and modulates BMP signalling....
19.
Cummins T, Wu K, Bozatzi P, Dingwell K, Macartney T, Wood N, et al.
J Cell Sci
. 2017 Nov;
131(1).
PMID: 29175910
Our previous studies of PAWS1 (protein associated with SMAD1; also known as FAM83G) have suggested that this molecule has roles beyond BMP signalling. To investigate these roles, we have used...
20.
Fulcher L, Hutchinson L, Macartney T, Turnbull C, Sapkota G
Open Biol
. 2017 May;
7(5).
PMID: 28490657
Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes. Similarly, RNA interference approaches...