Luke J Fulcher
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Explore the profile of Luke J Fulcher including associated specialties, affiliations and a list of published articles.
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12
Citations
300
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Recent Articles
1.
Fulcher L, Sobajima T, Batley C, Gibbs-Seymour I, Barr F
Nat Cell Biol
. 2025 Jan;
27(2):262-272.
PMID: 39789219
Delays in mitosis trigger p53-dependent arrest in G1 of the next cell cycle, thus preventing repeated cycles of chromosome instability and aneuploidy. Here we show that MDM2, the p53 ubiquitin...
2.
Sobajima T, Kowalczyk K, Skylakakis S, Hayward D, Fulcher L, Neary C, et al.
J Cell Biol
. 2023 Mar;
222(5).
PMID: 36897279
Amplification of the mitotic kinase Aurora A or loss of its regulator protein phosphatase 6 (PP6) have emerged as drivers of genome instability. Cells lacking PPP6C, the catalytic subunit of...
3.
Simpson L, Fulcher L, Sathe G, Brewer A, Zhao J, Squair D, et al.
Cell Chem Biol
. 2023 Jan;
30(2):188-202.e6.
PMID: 36720221
Reversible protein phosphorylation, catalyzed by protein kinases and phosphatases, is a fundamental process that controls protein function and intracellular signaling. Failure of phospho-control accounts for many human diseases. While a...
4.
An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins
Macartney T, Sapkota G, Fulcher L
Bio Protoc
. 2021 Oct;
7(22):e2614.
PMID: 34595287
We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) ( Fulcher , 2016 and 2017). AdPROM consists of the Von...
5.
Fulcher L, Sapkota G
Biochem J
. 2020 Dec;
477(23):4603-4621.
PMID: 33306089
Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly...
6.
Simpson L, Macartney T, Nardin A, Fulcher L, Roth S, Testa A, et al.
Cell Chem Biol
. 2020 Jul;
27(9):1164-1180.e5.
PMID: 32668203
The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI....
7.
Tachie-Menson T, Gazquez-Gutierrez A, Fulcher L, Macartney T, Wood N, Varghese J, et al.
Cell Signal
. 2020 Apr;
72:109632.
PMID: 32289446
The majority of mutations identified in patients with amelogenesis imperfecta have been mapped to FAM83H. As FAM83H expression is not limited to the enamel, how FAM83H contributes to amelogenesis is...
8.
Fulcher L, Sapkota G
Cell Cycle
. 2020 Feb;
19(5):505-524.
PMID: 32048898
The coordinated activities of many protein kinases, acting on multiple protein substrates, ensures the error-free progression through mitosis of eukaryotic cells. Enormous research effort has thus been devoted to studying...
9.
Fulcher L, He Z, Mei L, Macartney T, Wood N, Prescott A, et al.
EMBO Rep
. 2019 Jul;
20(9):e47495.
PMID: 31338967
The concerted action of many protein kinases helps orchestrate the error-free progression through mitosis of mammalian cells. The roles and regulation of some prominent mitotic kinases, such as cyclin-dependent kinases,...
10.
Roth S, Fulcher L, Sapkota G
Cell Mol Life Sci
. 2019 Apr;
76(14):2761-2777.
PMID: 31030225
Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types of protein silencing methodologies have been...