Thomas J Macartney
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Explore the profile of Thomas J Macartney including associated specialties, affiliations and a list of published articles.
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31
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1653
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Recent Articles
21.
Lai Y, Kondapalli C, Lehneck R, Procter J, Dill B, Woodroof H, et al.
EMBO J
. 2015 Oct;
34(22):2840-61.
PMID: 26471730
Mutations in the PTEN-induced kinase 1 (PINK1) are causative of autosomal recessive Parkinson's disease (PD). We have previously reported that PINK1 is activated by mitochondrial depolarisation and phosphorylates serine 65...
22.
Lachaud C, Castor D, Hain K, Munoz I, Wilson J, Macartney T, et al.
J Cell Sci
. 2014 May;
127(Pt 13):2811-7.
PMID: 24794496
Defects in SLX4, a scaffold for DNA repair nucleases, result in Fanconi anemia (FA), due to the defective repair of inter-strand DNA crosslinks (ICLs). Some FA patients have an SLX4...
23.
Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction
van der Wijst J, Blanchard M, Woodroof H, Macartney T, Gourlay R, Hoenderop J, et al.
Biochem J
. 2014 Mar;
460(2):165-75.
PMID: 24650431
Mutations in the gene that encodes the atypical channel-kinase TRPM6 (transient receptor potential melastatin 6) cause HSH (hypomagnesaemia with secondary hypocalcaemia), a disorder characterized by defective intestinal Mg2+ transport and...
24.
de Los Heros P, Alessi D, Gourlay R, Campbell D, Deak M, Macartney T, et al.
Biochem J
. 2014 Jan;
458(3):559-73.
PMID: 24393035
Precise homoeostasis of the intracellular concentration of Cl- is achieved via the co-ordinated activities of the Cl- influx and efflux. We demonstrate that the WNK (WNK lysine-deficient protein kinase)-activated SPAK...
25.
Castor D, Nair N, Declais A, Lachaud C, Toth R, Macartney T, et al.
Mol Cell
. 2013 Oct;
52(2):221-33.
PMID: 24076219
Holliday junctions (HJs) are X-shaped DNA structures that arise during homologous recombination, which must be removed to enable chromosome segregation. The SLX1 and MUS81-EME1 nucleases can both process HJs in ...
26.
Ohta A, Schumacher F, Mehellou Y, Johnson C, Knebel A, Macartney T, et al.
Biochem J
. 2013 Feb;
451(1):111-22.
PMID: 23387299
The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an important role in controlling mammalian blood pressure by modulating the activity of ion...
27.
Mehellou Y, Alessi D, Macartney T, Szklarz M, Knapp S, Elkins J
Biochem Biophys Res Commun
. 2013 Jan;
431(3):604-9.
PMID: 23296203
The MO25 scaffolding protein operates as critical regulator of a number of STE20 family protein kinases (e.g. MST and SPAK isoforms) as well as pseudokinases (e.g. STRAD isoforms that play...
28.
Davis E, Lachaud C, Appleton P, Macartney T, Nathke I, Rouse J
Nat Struct Mol Biol
. 2012 Oct;
19(11):1093-100.
PMID: 23042607
Ubiquitin-binding domains (UBDs) are crucial for recruiting many proteins to sites of DNA damage. Here we characterize C1orf124 (Spartan; referred to as DVC1), which has an UBZ4-type UBD found predominantly...
29.
Kondapalli C, Kazlauskaite A, Zhang N, Woodroof H, Campbell D, Gourlay R, et al.
Open Biol
. 2012 Jun;
2(5):120080.
PMID: 22724072
Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1...
30.
Duro E, Lundin C, Ask K, Sanchez-Pulido L, Macartney T, Toth R, et al.
Mol Cell
. 2010 Nov;
40(4):632-44.
PMID: 21055984
Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of stalled or broken DNA replication forks. Here we identify a human Mms22-like protein (MMS22L) and an MMS22L-interacting protein, NFκBIL2/TONSL....