Thomas J Macartney
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Explore the profile of Thomas J Macartney including associated specialties, affiliations and a list of published articles.
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31
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1653
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Recent Articles
1.
Brewer A, Zhao J, Fasimoye R, Shpiro N, Macartney T, Wood N, et al.
iScience
. 2024 Aug;
27(8):110423.
PMID: 39104417
TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases, including fibrosis and cancer. TGF-β transcriptional responses...
2.
Zhao J, Shpiro N, Sathe G, Brewer A, Macartney T, Wood N, et al.
iScience
. 2024 Jul;
27(8):110432.
PMID: 39081292
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplasm....
3.
Glennie L, Sola M, Xuncla M, Espanol G, Garcia-Arumi E, Tizzano E, et al.
Open Biol
. 2024 Jul;
14(7):240075.
PMID: 39043225
Palmoplantar keratoderma (PPK) is a multi-faceted skin disorder characterized by the thickening of the epidermis and abrasions on the palms and soles of the feet. Among the genetic causes, biallelic...
4.
Brewer A, Sathe G, Pflug B, Clarke R, Macartney T, Sapkota G
iScience
. 2024 Mar;
27(3):109302.
PMID: 38450154
Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic (C) subunit, with PPP2CA being the principal catalytic subunit....
5.
Roth S, Kocaturk N, Sathyamurthi P, Carton B, Watt M, Macartney T, et al.
Cell Chem Biol
. 2023 Aug;
30(10):1261-1276.e7.
PMID: 37591251
Targeted protein degradation (TPD), induced by enforcing target proximity to an E3 ubiquitin ligase using small molecules has become an important drug discovery approach for targeting previously undruggable disease-causing proteins....
6.
Carton B, Roth S, Macartney T, Sapkota G
Methods Enzymol
. 2023 Feb;
681:61-79.
PMID: 36764764
Targeted protein degradation (TPD) is a useful approach in dissecting protein function and therapeutics. Technologies such as RNA interference or gene knockout that are routinely used rely on protein turnover....
7.
An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins
Macartney T, Sapkota G, Fulcher L
Bio Protoc
. 2021 Oct;
7(22):e2614.
PMID: 34595287
We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) ( Fulcher , 2016 and 2017). AdPROM consists of the Von...
8.
Dunbar K, Macartney T, Sapkota G
Life Sci Alliance
. 2020 Dec;
4(2).
PMID: 33361334
Immunomodulatory imide drugs (IMiDs) bind CRBN, a substrate receptor of the Cul4A E3 ligase complex, enabling the recruitment of neo-substrates, such as CK1α, and their degradation via the ubiquitinproteasome system....
9.
Dunbar K, Jones R, Dingwell K, Macartney T, Smith J, Sapkota G
Life Sci Alliance
. 2020 Dec;
4(2).
PMID: 33361109
The function of the FAM83F protein, like the functions of many members of the FAM83 family, is poorly understood. Here, we show that injection of Fam83f mRNA into embryos causes...
10.
Bustos F, Segarra-Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, et al.
Dev Cell
. 2020 Oct;
55(5):629-647.e7.
PMID: 33080171
Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-rich splicing factor (SRSF) protein kinase (SRPK), which is...