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Thomas Hyde

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Articles 9
Citations 315
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Recent Articles
1.
Evans T, Feltrin A, Benjamin K, Katipalli T, Hyde T, Kleinman J, et al.
medRxiv . 2024 May; PMID: 38798538
DNA repetitive sequences (or repeats) comprise over 50% of the human genome and have a crucial regulatory role, specifically regulating transcription machinery. The human brain is the tissue with the...
2.
Daskalakis N, Iatrou A, Chatzinakos C, Jajoo A, Snijders C, Wylie D, et al.
Science . 2024 May; 384(6698):eadh3707. PMID: 38781393
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) included the central nucleus of the amygdala,...
3.
Clark M, Wrzesinski T, Garcia A, Hall N, Kleinman J, Hyde T, et al.
Mol Psychiatry . 2019 Nov; 25(1):37-47. PMID: 31695164
RNA splicing is a key mechanism linking genetic variation with psychiatric disorders. Splicing profiles are particularly diverse in brain and difficult to accurately identify and quantify. We developed a new...
4.
Jaffe A, Hyde T, Kleinman J, Weinberger D, Chenoweth J, McKay R, et al.
BMC Bioinformatics . 2016 Aug; 17:302. PMID: 27510709
No abstract available.
5.
Jaffe A, Hyde T, Kleinman J, Weinbergern D, Chenoweth J, McKay R, et al.
BMC Bioinformatics . 2015 Nov; 16:372. PMID: 26545828
Background: Genomic data production is at its highest level and continues to increase, making available novel primary data and existing public data to researchers for exploration. Here we explore the...
6.
Fysal Z, Hyde T, Barnes E, McCrea W, Ramcharitar S
Cardiovasc Revasc Med . 2014 Feb; 15(2):92-6. PMID: 24560297
Background/purpose: To evaluate the use of StentBoost® in the Tryton™ dedicated SideBranch Stent. Methods & Results: The Tryton™ SideBranch Stent has been effectively used to manage complex bifurcations. However, the...
7.
Kreisl W, Jenko K, Hines C, Lyoo C, Corona W, Morse C, et al.
J Cereb Blood Flow Metab . 2012 Sep; 33(1):53-8. PMID: 22968319
Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH),...
8.
Zhu G, Lipsky R, Xu K, Ali S, Hyde T, Kleinman J, et al.
Psychopharmacology (Berl) . 2004 Aug; 177(1-2):178-84. PMID: 15290009
Rationale: A common polymorphism, Val158Met, alters catechol- O-methyltransferase (COMT) enzyme activity and has been linked to psychiatric phenotypes. Bray et al. (2003) reported that COMT is subject to differential allele...
9.
Weickert T, Terrazas A, Bigelow L, Malley J, Hyde T, Egan M, et al.
Learn Mem . 2002 Dec; 9(6):430-42. PMID: 12464703
Different forms of nondeclarative learning involve regionally specific striatal circuits. The motor circuit (involving the putamen) has been associated with motor-skill learning and the dorsolateral prefrontal cortex (DLPFC) circuit (involving...