Thomas H Bugge
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Explore the profile of Thomas H Bugge including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Norregaard K, Jurgensen H, Heltberg S, Gardsvoll H, Bugge T, Schoof E, et al.
J Biol Chem
. 2024 Apr;
300(5):107284.
PMID: 38614208
Receptor-mediated cellular uptake of specific ligands constitutes an important step in the dynamic regulation of individual protein levels in extracellular fluids. With a focus on the inflammatory lung, we here...
2.
Strilchuk A, Hur W, Batty P, Sang Y, Abrahams S, Yong A, et al.
Sci Transl Med
. 2024 Feb;
16(735):eadh0027.
PMID: 38381848
Antifibrinolytic drugs are used extensively for on-demand treatment of severe acute bleeding. Controlling fibrinolysis may also be an effective strategy to prevent or lessen chronic recurring bleeding in bleeding disorders...
3.
Ehret E, Stroh S, Auberson M, Ino F, Jager Y, Maillard M, et al.
Cells
. 2023 Oct;
12(19).
PMID: 37830556
The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC in vivo. The present study...
4.
Szabo R, Kawaguchi M, Kataoka H, Bugge T
Development
. 2023 Aug;
150(17).
PMID: 37539662
Congenital tufting enteropathy (CTE) is a life-threatening intestinal disorder resulting from loss-of-function mutations in EPCAM and SPINT2. Mice deficient in Spint2, encoding the protease inhibitor HAI-2, develop CTE-like intestinal failure...
5.
Kim T, Silva L, Theofilou V, Greenwell-Wild T, Li L, Williams D, et al.
J Exp Med
. 2023 Jun;
220(9).
PMID: 37261457
Neutrophil infiltration is a hallmark of periodontitis, a prevalent oral inflammatory condition in which Th17-driven mucosal inflammation leads to destruction of tooth-supporting bone. Herein, we document that neutrophil extracellular traps...
6.
Zuo Z, Liu J, Sun Z, Cheng Y, Ewing M, Bugge T, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2211927120.
PMID: 36574698
The limited efficacy of the current antitumor microenvironment strategies is due in part to the poor understanding of the roles and relative contributions of the various tumor stromal cells to...
7.
Zuo Z, Liu J, Sun Z, Silverstein R, Zou M, Finkel T, et al.
PNAS Nexus
. 2022 Jul;
1(3):pgac104.
PMID: 35899070
FDA-approved BRAF and MEK small molecule inhibitors have demonstrated some level of efficacy in patients with metastatic melanomas. However, these "targeted" therapeutics have a very low therapeutic index, since these...
8.
Ehret E, Jager Y, Sergi C, Merillat A, Peyrollaz T, Anand D, et al.
Int J Mol Sci
. 2022 Jun;
23(12).
PMID: 35743186
The serine protease prostasin (CAP1/Prss8, channel-activating protease-1) is a confirmed in vitro and in vivo activator of the epithelial sodium channel ENaC. To test whether proteolytic activity or CAP1/Prss8 abundance...
9.
Szabo R, Ward J, Artunc F, Bugge T
Biol Open
. 2022 Jun;
11(7).
PMID: 35730316
Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein expressed on the surface of most epithelial and epithelium-derived tumor cells and reported to regulate stability of epithelial tight junction proteins,...
10.
Essigke D, Bohnert B, Janessa A, Worn M, Omage K, Kalbacher H, et al.
Pflugers Arch
. 2022 Mar;
474(6):613-624.
PMID: 35312839
Experimental nephrotic syndrome leads to activation of the epithelial sodium channel (ENaC) by proteolysis and promotes renal sodium retention. The membrane-anchored serine protease prostasin (CAP1/PRSS8) is expressed in the distal...