Thomas E Angel
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Explore the profile of Thomas E Angel including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
846
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Recent Articles
1.
Angel T, Chen Z, Moghieb A, Ng S, Beal A, Capriotti C, et al.
PLoS One
. 2025 Feb;
20(2):e0319216.
PMID: 39999142
Drugs targeting the ER-resident innate immune receptor Stimulator of Interferon Genes (STING) are in development for treatments of cancer and inflammatory diseases. Accurate determination of STING receptor levels in normal...
2.
Pu J, Xue C, Huo S, Shen Q, Qu Y, Yang X, et al.
Anal Chem
. 2022 Dec;
95(2):924-934.
PMID: 36534410
Accurate, absolute liquid chromatography-mass spectrometry (LC-MS)-based quantification of target proteins in formalin-fixed paraffin-embedded (FFPE) tissues would greatly expand sample availability for pharmaceutical/clinical investigations but remains challenging owing to the following...
3.
Naylor B, Anderson C, Hadfield M, Parkinson D, Ahlstrom A, Hannemann A, et al.
J Proteome Res
. 2022 Sep;
21(11):2703-2714.
PMID: 36099490
The synthesis of new proteins and the degradation of old proteins in vivo can be quantified in serial samples using metabolic isotope labeling to measure turnover. Because serial biopsies in...
4.
Kellie J, Sikorski T, An B, Chen Z, Moghieb A, Busz M, et al.
Bioanalysis
. 2019 Oct;
11(19):1731-1735.
PMID: 31617394
No abstract available.
5.
Angel T, Naylor B, Price J, Evans C, Szapacs M
Anal Chem
. 2019 Jul;
91(15):9732-9740.
PMID: 31259532
We describe an analytical strategy allowing for the direct quantification of stable isotope label incorporation in newly synthesized proteins following administration of the stable isotope tracer deuterium oxide. We present...
6.
Decaris M, Li K, Emson C, Gatmaitan M, Liu S, Wang Y, et al.
Hepatology
. 2016 Oct;
65(1):78-88.
PMID: 27706836
Conclusion: Using a well-characterized cohort of patients with biopsy-proven NAFLD, this study demonstrates that hepatic scar in NASH is actively remodeled even in advanced fibrosis, a disease that is generally...
7.
Shankaran M, King C, Angel T, Holmes W, Li K, Colangelo M, et al.
J Clin Invest
. 2015 Dec;
126(1):288-302.
PMID: 26657858
Here, we have described and validated a strategy for monitoring skeletal muscle protein synthesis rates in rodents and humans over days or weeks from blood samples. We based this approach...
8.
Decaris M, Emson C, Li K, Gatmaitan M, Luo F, Cattin J, et al.
PLoS One
. 2015 Apr;
10(4):e0123311.
PMID: 25909381
Accumulation and degradation of scar tissue in fibrotic liver disease occur slowly, typically over many years. Direct measurement of fibrogenesis, the rate of scar tissue deposition, may provide valuable therapeutic...
9.
Aryal U, Callister S, McMahon B, McCue L, Brown J, Stockel J, et al.
J Proteome Res
. 2014 May;
13(7):3262-76.
PMID: 24846609
Members of the cyanobacterial genus Cyanothece exhibit considerable variation in physiological and biochemical characteristics. The comparative assessment of the genomes and the proteomes has the potential to provide insights on...
10.
Smith J, Angel T, Chavkin C, Orton D, Moore R, Smith R
Proteomics
. 2014 Mar;
14(9):1102-6.
PMID: 24677814
Analysis of cerebrospinal fluid (CSF) offers key insight into the status of the CNS. Characterization of murine CSF proteomes can provide a valuable resource for studying CNS injury and disease...