Thomas A Owen
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Explore the profile of Thomas A Owen including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Owen T, Patel C, Wei S, Ho C, Birmingham K, Sanchez S, et al.
Gene
. 2020 Apr;
748:144668.
PMID: 32334025
KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP receptor agonists aimed at inducing local bone formation while avoiding the inherent side effects of systemic EP...
2.
Barrett S, Holt M, Kramer J, Germain B, Ho C, Ciske F, et al.
J Med Chem
. 2019 Apr;
62(9):4731-4741.
PMID: 30964292
A series of small-molecule full agonists of the prostaglandin E type 4 (EP) receptor have been generated and evaluated for binding affinity and cellular potency. KMN-80 and its gem-difluoro analog...
3.
Frara N, Abdelmagid S, Sondag G, Moussa F, Yingling V, Owen T, et al.
J Cell Physiol
. 2015 Apr;
231(1):72-83.
PMID: 25899717
Initial identification of osteoactivin (OA)/glycoprotein non-melanoma clone B (gpnmb) was demonstrated in an osteopetrotic rat model, where OA expression was increased threefold in mutant bones, compared to normal. OA mRNA...
4.
Arnott J, Lambi A, Mundy C, Hendesi H, Pixley R, Owen T, et al.
Crit Rev Eukaryot Gene Expr
. 2011 Oct;
21(1):43-69.
PMID: 21967332
Connective tissue growth factor (CTGF) is a 38 kDa, cysteine rich, extracellular matrix protein composed of 4 domains or modules. CTGF has been shown to regulate a diverse array of...
5.
Singh M, Del Carpio-Cano F, Belcher J, Crawford K, Frara N, Owen T, et al.
Crit Rev Eukaryot Gene Expr
. 2011 Mar;
20(4):341-57.
PMID: 21395506
Osteoactivin (OA) protein was discovered in bone cells a decade ago. Recent literature suggests that osteoactivin is crucial for the differentiation and functioning of different cell types, including bone-forming osteoblasts...
6.
Abdelmagid S, Barbe M, Hadjiargyrou M, Owen T, Razmpour R, Rehman S, et al.
J Cell Biochem
. 2010 May;
111(2):295-309.
PMID: 20506259
We previously identified osteoactivin (OA) as a novel secreted osteogenic factor with high expression in developing long bones and calvaria, and that stimulates osteoblast differentiation and matrix mineralization in vitro....
7.
Cameron K, Lefker B, Ke H, Li M, Zawistoski M, Tjoa C, et al.
Bioorg Med Chem Lett
. 2009 Mar;
19(7):2075-8.
PMID: 19250823
Sulfonamides, exemplified by 3a, were identified as highly selective EP(2) agonists. Lead optimization led to the identification of CP-533536, 7f, a potent and selective EP(2) agonist. CP-533536 demonstrated the ability...
8.
Abdelmagid S, Barbe M, Rico M, Salihoglu S, Arango-Hisijara I, Selim A, et al.
Exp Cell Res
. 2008 Jun;
314(13):2334-51.
PMID: 18555216
Osteoactivin (OA) is a novel glycoprotein that is highly expressed during osteoblast differentiation. Using Western blot analysis, our data show that OA protein has two isoforms, one is transmembranous and...
9.
Owen T, Pan L
Methods Mol Biol
. 2008 May;
455:3-18.
PMID: 18463807
Osteoblasts are the cells responsible for formation of new bone throughout life. Rats are one of the most widely studied mammalian species in skeletal biology and serve as useful models...
10.
Selim A, Castaneda J, Owen T, Popoff S, Safadi F
Med Sci Monit
. 2007 Dec;
13(12):BR259-70.
PMID: 18049427
Background: In our previous studies, we found that osteoactivin (OA) plays an important role in the regulation of osteoblast differentiation in vitro. Our studies also suggested that the region of...